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6/4/2026 7:37:44 AM | Browse: 0 | Download: 0
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Received |
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2026-03-26 03:41 |
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Peer-Review Started |
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2026-03-26 03:41 |
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First Decision by Editorial Office Director |
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2026-04-10 08:58 |
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Return for Revision |
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2026-04-10 08:58 |
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Revised |
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2026-04-24 08:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-09 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-09 06:15 |
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Articles in Press |
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2026-05-09 06:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-27 07:27 |
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Publish the Manuscript Online |
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2026-06-04 07:37 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Legal |
| Manuscript Type |
Opinion Review |
| Article Title |
Single-cell deoxyribonucleic acid typing for forensic mixtures and trace evidence: Opportunities, validation requirements, and reporting limits
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kyriacos Evangelou, Paraskevi Angeli, Andreas Polydorou and Thalia Petropoulou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kyriacos Evangelou, MD, Department of Minimally Invasive Colon and Rectal Surgery, The Euroclinic Hospital of Athens, 7-9 Athanasiadou & D. Soutsou Street, Athens 11521, Greece. evangeloukyriacos@gmail.com |
| Key Words |
Forensic genetics; Single-cell genomics; Deoxyribonucleic acid mixtures; Laser capture microdissection; Digital cell sorting; Whole-genome amplification; Short tandem repeats; Activity-level propositions; Deoxyribonucleic acid transfer |
| Core Tip |
Single-cell forensic deoxyribonucleic acid (DNA) typing has moved beyond speculation, but present evidence supports targeted use only in validated niches. Its forensic value lies in reducing mixture complexity before computation, preserving cell-of-origin information, and rescuing contributor profiles that bulk analysis may not resolve. Its forensic risk lies in selective cell capture, single-template stochasticity, contamination at near-single-copy sensitivity, and the temptation to over-read cellular context as activity-level proof. The appropriate translational question is therefore not whether single-cell short tandem repeat typing works in principle, but which minimum validation thresholds and reporting limits are necessary before it enters accredited casework. |
| Publish Date |
2026-06-04 07:37 |
| Citation |
Evangelou K, Angeli P, Polydorou A, Petropoulou T. Single-cell deoxyribonucleic acid typing for forensic mixtures and trace evidence: Opportunities, validation requirements, and reporting limits. World J Biol Chem 2026; 17(2): 121467
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| URL |
https://www.wjgnet.com/1949-8454/full/v17/i2/121467.htm |
| DOI |
https://doi.org/10.4331/wjbc.v17.i2.121467 |
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