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Articles Published Processes
6/22/2026 8:41:00 AM | Browse: 0 | Download: 0
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Received |
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2026-03-25 00:43 |
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Peer-Review Started |
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2026-03-25 00:45 |
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First Decision by Editorial Office Director |
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2026-04-04 02:35 |
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Return for Revision |
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2026-04-04 02:35 |
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Revised |
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2026-04-13 17:03 |
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Publication Fee Transferred |
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2026-04-17 18:20 |
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Second Decision by Editor |
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2026-06-02 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-02 08:38 |
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Articles in Press |
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2026-06-02 08:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-09 03:00 |
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Publish the Manuscript Online |
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2026-06-22 08:41 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Public, Environmental & Occupational Health |
| Manuscript Type |
Minireviews |
| Article Title |
From residue to cancer risk: How thirdhand smoke drives cancer hallmarks
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Hua Mao and Hang Chang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the University of California Tobacco Related Disease Research Program (UC TRDRP) |
No. T32PT6221 |
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| Corresponding Author |
Hang Chang, PhD, Principal Investigator, Division of Biological Systems and Engineering, Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, United States. hchang@lbl.gov |
| Key Words |
Environmental carcinogenesis; Thirdhand smoke; Cancer hallmarks; Nicotine-derived tobacco-specific nitrosamines; Polycyclic aromatic hydrocarbons; Heavy metals; Risk assessment |
| Core Tip |
Thirdhand smoke (THS) represents a persistent and underrecognized environmental carcinogen whose complex chemical mixture drives cancer-relevant biological processes beyond the window of active smoking. By integrating THS-induced molecular and cellular perturbations, such as DNA damage, epigenetic reprogramming, oxidative stress, and chronic inflammation, within the framework of the hallmarks of cancer, a systems-level paradigm for carcinogenic risk assessment emerges. This approach moves beyond traditional single-endpoint toxicology to capture the cumulative, multi-pathway impact of chronic low-dose exposures. Applying this framework to THS reveals how residual tobacco toxicants synergistically disrupt multiple cancer hallmarks, providing a mechanistically grounded basis for evaluating long-term cancer risk and informing environmental health policy. |
| Publish Date |
2026-06-22 08:41 |
| Citation |
Mao JH, Chang H. From residue to cancer risk: How thirdhand smoke drives cancer hallmarks. World J Clin Oncol 2026; 17(6): 121469
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i6/121469.htm |
| DOI |
https://doi.org/10.5306/wjco.121469 |
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