7/20/2026 7:08:28 AM | Browse: 2 | Download: 13
| Publication Name | World Journal of Cardiology |
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| Manuscript ID | 121472 |
| Country | United States |
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| ISSN | 1949-8462 (online) |
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| Open Access | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Cardiac & Cardiovascular Systems | ||||||
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| Manuscript Type | Meta-Analysis | ||||||
| Article Title | Preventing anthracycline-induced cardiotoxicity with ivabradine: A systematic review and meta-analysis | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Rohab Sohail, Ridda Khattak, Haider Hussain Shah, Zaraq Khan, Shafaq Jawed, Asad Ullah Wasim, Bisma Akram, Rohan Patel, Simran Patel, Madihah Alam, Shahryar Chaudhry, Samar Mehdi, Vyom Patel and Manjeet Singh | ||||||
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| Corresponding Author | Rohab Sohail, MD, Department of Internal Medicine, Bayhealth Medical Center, 640 South State Street, Dover, DE 19904, United States. rohabsohail98@gmail.com | ||||||
| Key Words | Ivabradine; Anthracycline-induced cardiotoxicity; Malignancy; Left ventricular ejection fraction; Global longitudinal strain; Blood pressure; Troponin | ||||||
| Core Tip | Anthracyclines-induced chemotherapy is associated with a risk of cardiotoxicity, often manifesting as reductions in left ventricular ejection fraction and subclinical myocardial injury. In this meta-analysis of randomized studies, ivabradine did not demonstrate a significant effect in preserving left ventricular ejection fraction or improving cardiac biomarkers, including troponin and NT-proBNP, nor did it significantly reduce global longitudinal strain deterioration. These findings suggest that while ivabradine is well tolerated and does not adversely affect blood pressure, current evidence does not support its routine use for the prevention of anthracycline-induced cardiotoxicity. Larger randomized trials are needed to clarify its potential cardioprotective role. | ||||||
| Publish Date | 2026-07-20 07:08 | ||||||
| Citation |
Sohail R, Khattak R, Shah HH, Khan Z, Jawed S, Wasim AU, Akram B, Patel R, Patel S, Alam M, Chaudhry S, Mehdi S, Patel V, Singh M. Preventing anthracycline-induced cardiotoxicity with ivabradine: A systematic review and meta-analysis. World J Cardiol 2026; 18(7): 121472 |
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| URL | https://www.wjgnet.com/1949-8462/full/v18/i7/121472.htm | ||||||
| DOI | https://doi.org/10.4330/wjc.v18.i7.121472 |
| Full Article (PDF) | WJC-18-121472-with-cover.pdf |
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| PRISMA 2009 Checklist | 121472-PRISMA-2009-Checklist.pdf |
| Manuscript File | 121472_Auto_Edited_033539.docx |
| Answering Reviewers | 121472-answering-reviewers.pdf |
| Audio Core Tip | 121472-audio.mp3 |
| Biostatistics Review Certificate | 121472-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 121472-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 121472-copyright-assignment.pdf |
| Supplementary Material | 121472-supplementary-material.pdf |
| Peer-review Report | 121472-peer-reviews.pdf |
| Scientific Misconduct Check | 121472-scientific-misconduct-check.png |
| Scientific Editor Work List | 121472-scientific-editor-work-list.pdf |
| CrossCheck Report | 121472-crosscheck-report.pdf |