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Publication Name World Journal of Gastroenterology
Manuscript ID 1215
Country/Territory Brazil
Received
2012-11-21 20:50
Peer-Review Started
2012-11-22 16:03
To Make the First Decision
2012-12-21 17:26
Return for Revision
2012-12-24 09:28
Revised
2013-03-09 02:24
Second Decision
2013-04-09 20:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-04-10 07:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-05-17 20:30
Publish the Manuscript Online
2013-05-28 09:36
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults
Manuscript Source Invited Manuscript
All Author List Marisa C Alvarez, Juliana C Santos, Nathália Maniezzo, Marcelo S Ladeira, Artur LC da Silva, Isabel CA Scaletsky, José Pedrazzoli Jr and Marcelo L Ribeiro
Funding Agency and Grant Number
Funding Agency Grant Number
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo 2009/01813-0
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo 2008/02678-6
Conselho Nacional de Desenvolvimento Científico e Tecnológico 471088/2007-2
Corresponding author Marcelo L Ribeiro, PhD, Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista 12916-900, SP, Brazil. marcelo.ribeiro@usf.edu.br
Keywords Helicobacter pylori; Microsatellite instability; Promoter methylation; MLH1; MGMT; Gastric cancer
Core Tip Gastric carcinogenesis is a multistep process that is triggered by Helicobacter pylori (H. pylori) infection and characterised by multiple genetic and epigenetic alterations, including the DNA repair genes. To date, few advances have been made to determine the time duration required for to H. pylori infection to induce such epigenetics alteration and thus potentially induce gastric carcinogenesis. The results presented in this study indicate that the methylation of the MGMT and MLH1 promoter regions might depend on the duration of infection because these methylation events were not observed in children.
Publish Date 2013-05-28 09:36
Citation Alvarez MC, Santos JC, Maniezzo N, Ladeira MS, da Silva ALC, Scaletsky ICA, Pedrazzoli Jr J, Ribeiro ML. MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults. World J Gastroenterol 2013; 19(20): 3043-3051
Url http://www.wjgnet.com/1007-9327/full/v19/i20/3043.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i20.3043
Full Article (PDF) WJG-19-3043.pdf
Manuscript File 1215-Review.doc
Answering Reviewers 1215-Answering reviewers.doc
Copyright License Agreement 1215-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 1215-Language certificate.pdf
Peer-review Report 1215-Peer review(s).pdf
Scientific Editor Work List 1215-Scientific editor work list.doc