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Articles Published Processes
10/27/2026 6:30:55 AM | Browse: 1 | Download: 0
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Received |
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2026-03-26 02:03 |
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Peer-Review Started |
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2026-03-26 02:04 |
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First Decision by Editorial Office Director |
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2026-04-03 10:29 |
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Return for Revision |
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2026-04-03 10:29 |
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Revised |
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2026-04-26 18:00 |
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Publication Fee Transferred |
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2026-04-30 08:51 |
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Second Decision by Editor |
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2026-06-09 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-09 08:15 |
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Articles in Press |
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2026-06-09 08:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-19 00:17 |
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Publish the Manuscript Online |
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2026-10-27 06:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Ting Peng, Fei-Lan Yang, Shi-Fang Peng and Lei Fu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82570747 |
| Provincial Natural Science Foundation of Hunan Province |
No. 2022JJ30954 |
| Provincial Natural Science Foundation of Hunan Province |
No. 2025JJ50599 |
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| Corresponding Author |
Lei Fu, PhD, Professor, Department of Infectious Diseases, Xiangya Hospital Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. fulei92@126.com |
| Key Words |
Immune checkpoint inhibitors; Liver injury; Predictive model; T cell subpopulation; Complement; Immune-mediated hepatitis |
| Core Tip |
This retrospective study of 544 cancer patients receiving immune checkpoint inhibitors identifies baseline peripheral cluster of differentiation (CD) 3+ CD8+ T cell counts as a novel independent predictor of immune-mediated hepatitis. Integrating this immune parameter with alanine transaminase and complement 4, the authors constructed a nomogram that achieved good discriminatory performance (area under the curve 0.81 in training and 0.80 in validation). This model provides a clinically accessible tool for pre-treatment risk stratification. |
| Publish Date |
2026-10-27 06:30 |
| Citation |
Peng WT, Yang FL, Peng SF, Fu L. Real-world predictive model for immune checkpoint inhibitor-induced hepatitis using baseline cytotoxic T-lymphocyte counts. World J Gastroenterol 2026; 32(47): 121501
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i47/121501.htm |
| DOI |
https://doi.org/10.3748/wjg.121501 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
