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9/20/2026 3:29:00 AM | Browse: 0 | Download: 0
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Received |
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2026-03-26 00:50 |
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Peer-Review Started |
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2026-03-26 01:11 |
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First Decision by Editorial Office Director |
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2026-04-21 10:03 |
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Return for Revision |
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2026-04-21 10:03 |
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Revised |
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2026-05-26 17:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-17 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-17 03:01 |
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Articles in Press |
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2026-06-17 03:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-29 06:38 |
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Publish the Manuscript Online |
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2026-09-20 03:29 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pooja Jayaraman Thirunavukkarasu, Arunagiri Gunasekar, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Viji Devanand, Sanjeevi Bharadwaj and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Bone-specific alkaline phosphatase; Osteoblast; Wnt/β-catenin; Skeletal metabolism; Bone formation |
| Core Tip |
Bone-specific alkaline phosphatase (BSAP) is a good indicator of osteoblastic bone formation, released by osteoblasts as the matrix matures and becomes mineralized. In contrast to imaging, BSAP reflects metabolic activity, increasing early with anabolic therapies and helping to differentiate bone disorders, including Paget’s disease, hypophosphatasia and chronic kidney disease-related bone disease. However, due to the difficulties in standardization and in having norm values, BSAP’s combination with imaging and artificial intelligence models holds the promise of a more accurate and personalized approach to skeletal health. |
| Publish Date |
2026-09-20 03:29 |
| Citation |
Thirunavukkarasu PJ, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Devanand V, Bharadwaj S, Jeyaraman M. Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates. World J Exp Med 2026; 16(3): 121518
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| URL |
https://www.wjgnet.com/2220-315x/full/v16/i3/121518.htm |
| DOI |
https://doi.org/10.5493/wjem.121518 |
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