| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Yu Zhu, Meng Yuan, Xiao-Chang Wen, Chen-Chen Tian, Yue-Hua Han, Chen Zheng, Yun-Tao Wu, Qun Xia and Yue Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81273520 |
| Tianjin Key Medical Discipline Construction Project (Orthopedics) |
No. TJYXZDXK-3-005A |
| Great Program of the Science Foundation of Tianjin |
No. 18JCZDJC33200 |
|
| Corresponding Author |
Yue Wang, PhD, Professor, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyang Lake Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China. wangyue6806@tjutcm.edu.cn |
| Key Words |
Osthole; Bone; Estrogen receptor; Phosphoinositide 3-kinase/protein kinase B; Mitogen-activated protein kinase kinase/extracellular signal-regulated kinase; Wnt/β-catenin |
| Core Tip |
This study elucidates that osthole, a natural coumarin compound, exerts osteoprotective effects through a novel multi-target mechanism involving simultaneous activation of estrogen receptor, phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase kinase/extracellular signal-regulated kinase, and Wnt/β-catenin signaling pathways in osteoblasts. By directly promoting osteoblast function and indirectly inhibiting osteoclast differentiation via osteoprotegerin/receptor activator of nuclear factor-κB ligand modulation, osthole emerges as a promising natural therapeutic candidate for osteoporosis. |
| Publish Date |
2026-10-16 05:20 |
| Citation |
Zhu TY, Yuan M, Wen XC, Tian CC, Han YH, Zheng C, Wu YT, Xia Q, Wang Y. Osthole exerts osteoprotective effect by activating ER, PI3K/AKT, MEK/ERK, and Wnt/β-catenin signaling pathways. World J Orthop 2026; 17(10): 121526
|
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i10/121526.htm |
| DOI |
https://doi.org/10.5312/wjo.121526 |
