| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Araj Naveed Siddiqui, Rabia Hafsa, Vikash Kumar Karmani, Zainab Rehan and Rishi Chowdhary |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Rishi Chowdhary, MD, Department of Medicine, MetroHealth Medical Center, Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA., Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. rxc822@case.edu, Cleveland, 44109, United States. rxc822@case.edu |
| Key Words |
Cronkhite-Canada syndrome; Gastrointestinal polyposis; Pathogenesis; Diagnosis; Therapies |
| Core Tip |
Cronkhite-Canada syndrome is a rare, non-hereditary gastrointestinal (GI) polyposis disorder with multisystem involvement and significant diagnostic challenges due to its overlap with more common GI diseases. This review provides a comprehensive synthesis of current evidence, highlighting emerging insights into its multifactorial pathogenesis, including immune dysregulation, microbiome alterations, and potential infectious triggers. It also emphasizes the evolving role of immunosuppressive and biologic therapies alongside nutritional support. By integrating clinical features, diagnostic strategies, and therapeutic approaches, this article proposes a structured framework to improve early recognition, guide management, and reduce long-term complications, including malignancy. |
| Publish Date |
2026-09-08 03:16 |
| Citation |
Siddiqui AN, Hafsa R, Karmani VK, Rehan Z, Chowdhary R. Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies. World J Gastrointest Pathophysiol 2026; 17(3): 121535
|
| URL |
https://www.wjgnet.com/2150-5330/full/v17/i3/121535.htm |
| DOI |
https://doi.org/10.4291/wjgp.121535 |
