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Publication Name World Journal of Transplantation
Manuscript ID 121567
Country United States
Received
2026-03-27 03:22
Peer-Review Started
2026-03-27 03:24
First Decision by Editorial Office Director
2026-04-08 08:46
Return for Revision
2026-04-08 08:46
Revised
2026-04-20 03:05
Publication Fee Transferred
Second Decision by Editor
2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-08 10:52
Articles in Press
2026-05-08 10:52
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-29 10:09
Publish the Manuscript Online
2026-09-02 06:21
ISSN 2220-3230 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright Early allograft dysfunction (EAD) remains common in liver transplantation, affecting roughly 20%-25% of recipients of allografts preserved via static cold storage, the traditional mode of organ preservation. Dynamic changes in serum cytokine and transcription factor levels - lower baseline interleukin-6, rising interferon-gamma-induced protein 10 peri-implantation, and elevated post-implantation hypoxia inducible factor-1 alpha are associated with EAD, suggesting potential early biomarkers. After validation in a larger study, peri-implantation biomarker profiling may help identify high-risk allografts early, potentially guiding management.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anesthesiology
Manuscript Type Observational Study
Article Title Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study
Manuscript Source Invited Manuscript
All Author List Elizabeth A Wilson, Ammar Rashied, Jamie R Privratsky, Mara Serbanescu, Andrew S Barbas, Kirsten M Williams and Craig M Coopersmith
ORCID
Author(s) ORCID Number
Elizabeth A Wilson http://orcid.org/0000-0002-8105-0928
Jamie R Privratsky http://orcid.org/0000-0003-3598-4911
Mara Serbanescu http://orcid.org/0000-0002-5356-1130
Andrew S Barbas http://orcid.org/0000-0003-3476-2313
Kirsten M Williams http://orcid.org/0000-0001-9372-5286
Craig M Coopersmith http://orcid.org/0000-0003-2400-3217
Funding Agency and Grant Number
Funding Agency Grant Number
the Robert W Woodruff Health Science Center and the National Center for Advancing Translational Sciences of the National Institutes of Health under Award UL1TR002378
International Liver Transplantation Society Vanguard Award
the National Institutes of Health held by CMC 5R35GM148217-04
Corresponding Author Elizabeth A Wilson, Assistant Professor, MD, Principal Investigator, Department of Anesthesiology, Duke University School of Medicine, 2301 Erwin Road, Durham, NC 27707, United States. elizabeth.a.wilson@duke.edu
Key Words Early allograft dysfunction; Ischemia reperfusion injury; Oxidative stress; Biomarkers; Liver transplantation
Core Tip Early allograft dysfunction (EAD) remains common in liver transplantation, affecting roughly 20%-25% of recipients of allografts preserved via static cold storage, the traditional mode of organ preservation. Dynamic changes in serum cytokine and transcription factor levels - lower baseline interleukin-6, rising interferon-gamma-induced protein 10 peri-implantation, and elevated post-implantation hypoxia inducible factor-1 alpha are associated with EAD, suggesting potential early biomarkers. After validation in a larger study, peri-implantation biomarker profiling may help identify high-risk allografts early, potentially guiding management.
Publish Date 2026-09-02 06:21
Citation

Wilson EA, Rashied A, Privratsky JR, Serbanescu M, Barbas AS, Williams KM, Coopersmith CM. Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study. World J Transplant 2026; 16(3): 121567
URL https://www.wjgnet.com/2220-3230/full/v16/i3/121567.htm
DOI https://doi.org/10.5500/wjt.121567
Full Article (PDF) WJT-16-121567-with-cover.pdf
STROBE Statement 121567-STROBE-statement.pdf
Manuscript File 121567_Auto_Edited_032822.docx
Answering Reviewers 121567-answering-reviewers.pdf
Audio Core Tip 121567-audio.mp3
Biostatistics Review Certificate 121567-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 121567-conflict-of-interest-statement.pdf
Copyright License Agreement 121567-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 121567-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 121567-institutional-review-board-statement.pdf
Supplementary Material 121567-supplementary-material.pdf
Peer-review Report 121567-peer-reviews.pdf
Scientific Misconduct Check 121567-scientific-misconduct-check.png
CrossCheck Report 121567-crosscheck-report.pdf
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