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Articles Published Processes
9/15/2026 7:51:37 AM | Browse: 3 | Download: 0
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Received |
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2026-03-31 03:54 |
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Peer-Review Started |
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2026-03-31 03:56 |
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First Decision by Editorial Office Director |
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2026-04-21 09:10 |
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Return for Revision |
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2026-04-21 09:10 |
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Revised |
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2026-05-12 06:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-16 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-16 06:45 |
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Articles in Press |
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2026-06-16 06:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-07 03:44 |
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Publish the Manuscript Online |
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2026-09-15 07:51 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Minireviews |
| Article Title |
Pulmonary metastasectomy for recurrent hepatocellular carcinoma after liver transplantation: A therapeutic challenge
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alessandro Pardolesi, Michele Ferrari, Giovanni Leuzzi, Edoardo Ceruti, Ugo Cioffi, Matilde De Simone, Gerardo Cioffi and Piergiorgio Solli |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Michele Ferrari, Department of Thoracic Surgery, Istituto Nazionale Tumori, Via G.Venezian 1, Milan 20133, Lombardy, Italy. michele.ferrari@istitutotumori.mi.it |
| Key Words |
Hepatocellular carcinoma; Pulmonary metastasectomy; Liver transplantation; Recurrence; Tumor biology |
| Core Tip |
Liver transplantation is a definitive treatment for hepatocellular carcinoma, yet recurrence occurs 8%-20% of patients, with the lung being the most common extra-hepatic site. Pulmonary metastasectomy offers meaningful survival benefit in carefully selected patients with resectable, lung-limited disease and favorable tumor biology. Patient selection should prioritize disease-free survival, alpha-fetoprotein levels, and oligometastatic pattern, rather than immunosuppression management alone. We emphasize the need for rigorous, biology-driven selection criteria and prospective studies to define the role of surgery within a multimodal approach to extra-hepatic hepatocellular carcinoma recurrence. |
| Publish Date |
2026-09-15 07:51 |
| Citation |
Pardolesi A, Ferrari M, Leuzzi G, Ceruti E, Cioffi U, De Simone M, Cioffi G, Solli P. Pulmonary metastasectomy for recurrent hepatocellular carcinoma after liver transplantation: A therapeutic challenge. World J Gastrointest Surg 2026; 18(9): 121591
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| URL |
https://www.wjgnet.com/1948-9366/full/v18/i9/121591.htm |
| DOI |
https://doi.org/10.4240/wjgs.121591 |
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