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Articles Published Processes
11/6/2026 1:05:19 AM | Browse: 2 | Download: 1
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Received |
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2026-04-07 00:34 |
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Peer-Review Started |
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2026-04-12 23:53 |
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First Decision by Editorial Office Director |
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2026-04-28 00:59 |
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Return for Revision |
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2026-04-28 00:59 |
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Revised |
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2026-05-14 12:10 |
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Publication Fee Transferred |
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2026-05-19 08:07 |
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Second Decision by Editor |
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2026-07-06 07:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-24 08:42 |
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Articles in Press |
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2026-09-24 08:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-29 07:48 |
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Publish the Manuscript Online |
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2026-11-06 01:05 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Postmenopausal high-gonadotropin-releasing hormone environment mediates pancreatic β-cell compensation via the cAMP-PKA-PDX1 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Juan Dai, Shi-Cong Gao, Peng-Tao Chen, Lu Yang, Chu-Chu Kong, Cui-Ying Ye, Zi-Xuan Xu, Ya-Xin Hu, Cheng-Yong He, Zheng-Hong Zuo and Wei Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei Wang, Professor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2000 Xiang’an East Road, Xiang’an District, Xiamen 361102, Fujian Province, China. wwang@xah.xmu.edu.cn |
| Key Words |
Gonadotropin-releasing hormone; Gonadotropin-releasing hormone receptor; Pancreatic β-cells; Insulin secretion; Menopause |
| Core Tip |
This study examines the metabolic significance of elevated gonadotropin-releasing hormone (GnRH) in the postmenopausal state. We found that GnRH receptor is preferentially expressed in pancreatic β-cells and that GnRH enhances insulin secretion through the cAMP-PKA-PDX1 signaling pathway. These findings suggest that postmenopausal hypothalamic-pituitary-gonadal axis remodeling may contribute to β-cell compensation and provide a mechanistic link between reproductive endocrine aging and glucose homeostasis. |
| Publish Date |
2026-11-06 01:05 |
| Citation |
Dai XJ, Gao SC, Chen PT, Yang L, Kong CC, Ye CY, Xu ZX, Hu YX, He CY, Zuo ZH, Wang W. Postmenopausal high-gonadotropin-releasing hormone environment mediates pancreatic β-cell compensation via the cAMP-PKA-PDX1 pathway. World J Diabetes 2026; 17(11): 121630
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i11/121630.htm |
| DOI |
https://doi.org/10.4239/wjd.121630 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
