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Articles Published Processes
7/24/2026 6:11:14 AM | Browse: 1 | Download: 0
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Received |
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2026-03-30 08:11 |
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Peer-Review Started |
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2026-03-30 08:16 |
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First Decision by Editorial Office Director |
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2026-04-23 09:54 |
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Return for Revision |
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2026-04-23 10:51 |
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Revised |
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2026-05-12 08:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-22 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-22 03:24 |
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Articles in Press |
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2026-06-22 03:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-16 01:48 |
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Publish the Manuscript Online |
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2026-07-24 06:11 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zi-Jin Sun, Kai Wang, Jin-Qiao Li, Lin-Jing Song, Kang-Ni Liang, Ting-Lan Cao and Hui-Zhong Jiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui-Zhong Jiang, PhD, Professor, Researcher, Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Beijing 100700, China. jianghz93@126.com |
| Key Words |
Gastrointestinal neoplasms; Cuproptosis; Metabolic reprogramming; Ferredoxin 1; Nanomedicine; Traditional Chinese medicine; Gut microbiota |
| Core Tip |
Gastrointestinal malignancies exhibit profound metabolic reprogramming and “cuproplasia”, heavily relying on copper homeostasis for progression and drug resistance. Targeting cuproptosis - a ferredoxin 1-mediated cell death causing toxic aggregation of lipoylated proteins like dihydrolipoamide S-acetyltransferase - offers a transformative strategy to bypass conventional therapeutic resistance. This review highlights multifaceted interventions, including repurposing synthetic copper ionophores, leveraging traditional Chinese medicine phytochemicals, and modulating the unique “dietary copper-gut microbiota” axis. Furthermore, deploying stimuli-responsive nanomedicines helps overcome dense stromal barriers and induces immunogenic cell death, synergizing with immunotherapy to advance the precision management of refractory gastrointestinal tumors. |
| Publish Date |
2026-07-24 06:11 |
| Citation |
Sun ZJ, Wang K, Li JQ, Song LJ, Liang KN, Cao TL, Jiang HZ. Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy. World J Clin Oncol 2026; 17(7): 121645
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i7/121645.htm |
| DOI |
https://doi.org/10.5306/wjco.121645 |
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