BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/3/2026 2:08:41 AM | Browse: 1 | Download: 0
 |
Received |
|
2026-03-30 07:41 |
|
Peer-Review Started |
|
2026-03-30 07:45 |
|
First Decision by Editorial Office Director |
|
2026-06-05 08:10 |
|
Return for Revision |
|
2026-07-03 19:59 |
|
Revised |
|
2026-07-12 13:41 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-07-28 02:34 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-07-28 13:26 |
|
Articles in Press |
|
2026-07-28 13:26 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-09-01 02:51 |
|
Publish the Manuscript Online |
|
2026-09-03 02:08 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Minireviews |
| Article Title |
Mortality despite new generation medications for pediatric neuromuscular diseases and how to prevent it
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Maninderpal Kaur and John R Bach |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Maninderpal Kaur, Assistant Professor, MD, Department of Medicine, Rutgers New Jersey Medical School, University Hospital, 150 Bergen Street, H245, Newark, NJ 07103, United States. mk1786@njms.rutgers.edu |
| Key Words |
Noninvasive ventilation; Noninvasive ventilatory support; Neuromuscular diseases; Mechanical insufflation exsufflation; Spinal muscular atrophy; Muscular dystrophy; Extubation; Decannulation |
| Core Tip |
New gene and RNA-based therapies slow progression of pediatric neuromuscular diseases but do not restore effective cough. When hypoxic episodes are treated with supplemental oxygen instead of noninvasive ventilatory support (NVS) and mechanical insufflation-exsufflation (MIE), CO2 narcosis, intubation, and unnecessary tracheostomy or death often follow. Extubating ventilator-unweanable patients directly to continuous NVS and MIE, rather than pursuing prolonged weaning trials, allows most to return to their prior ventilator-use regimens without tracheostomy. This approach also saves over $500000 per patient annually in nursing and medical costs while preserving quality of life. |
| Publish Date |
2026-09-03 02:08 |
| Citation |
Kaur M, Bach JR. Mortality despite new generation medications for pediatric neuromuscular diseases and how to prevent it. World J Transl Med 2026; 12(3): 121646
|
| URL |
https://www.wjgnet.com/2220-6132/full/v12/i3/121646.htm |
| DOI |
https://doi.org/10.5528/wjtm.121646 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
