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Articles Published Processes
8/20/2026 6:54:16 AM | Browse: 2 | Download: 10
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Received |
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2026-03-31 05:57 |
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Peer-Review Started |
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2026-03-31 06:00 |
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First Decision by Editorial Office Director |
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2026-04-21 09:16 |
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Return for Revision |
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2026-04-21 09:16 |
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Revised |
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2026-05-19 00:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-12 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-15 07:06 |
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Articles in Press |
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2026-06-15 07:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-11 04:15 |
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Publish the Manuscript Online |
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2026-08-20 06:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Minireviews |
| Article Title |
From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bo-Lin Zhang, Shinichiro Kobayashi, Lu-Yang Li, Tian-Yang Li, Shinichiro Ogawa, Daisuke Miyamoto, Kayo Hasegawa, Shun Yamaguchi, Tomohiko Adachi, Susumu Eguchi and Kengo Kanetaka |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research C |
24K11935 |
| Japan Agency for Medical Research and Development |
25ym0126811j0004 |
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| Corresponding Author |
Shinichiro Kobayashi, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki 852-8501, Japan. skobayashi1980@gmail.com |
| Key Words |
Cell sheet technology; Mesenchymal stem cells; Myoblasts; Regenerative medicine; Inflammatory bowel disease; Crohn’s disease |
| Core Tip |
Crohn’s disease fistulas remain a clinical challenge because current therapies mainly suppress inflammation without restoring the damaged tissue’s architecture. This review highlights cell sheet technology as a scaffold-free regenerative platform with superior cell retention, extracellular matrix preservation, and sustained paracrine activity. While mesenchymal stem cell therapies mainly provide regulatory repair, myoblast cell sheets add intrinsic myogenic potential, enabling reconstruction of the disrupted muscle layer and functional tissue recovery. By shifting the therapeutic goal from inflammation control to structural regeneration, myoblast cell sheets may offer a next-generation strategy for the durable repair of complex Crohn’s disease fistulas. |
| Publish Date |
2026-08-20 06:54 |
| Citation |
Zhang BL, Kobayashi S, Li LY, Li TY, Ogawa S, Miyamoto D, Hasegawa K, Yamaguchi S, Adachi T, Eguchi S, Kanetaka K. From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease. World J Stem Cells 2026; 18(8): 121648
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i8/121648.htm |
| DOI |
https://doi.org/10.4252/wjsc.121648 |
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