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9/3/2026 2:49:01 AM | Browse: 0 | Download: 0
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Received |
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2026-04-01 07:44 |
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Peer-Review Started |
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2026-04-01 07:45 |
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First Decision by Editorial Office Director |
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2026-04-17 08:15 |
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Return for Revision |
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2026-04-17 08:15 |
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Revised |
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2026-05-11 07:33 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-08 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-08 09:32 |
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Articles in Press |
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2026-06-08 09:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-01 08:14 |
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Publish the Manuscript Online |
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2026-09-03 02:49 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daiki Imanishi, Hinano Nishikubo, Dongheng Ma, Tomoya Sano, Canfeng Fan, Takashi Sakuma and Masakazu Yashiro |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants-in-Aid for Scientific Research |
No. 24K02525 |
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| Corresponding Author |
Masakazu Yashiro, MD, PhD, Department of Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 5458585, Japan. i21496f@omu.ac.jp |
| Key Words |
Transforming growth factor beta 2; Gastric cancer; Cancer-associated fibroblasts; Tumor microenvironment |
| Core Tip |
The immunohistochemical analysis of gastric carcinoma was performed to clarify the clinical function of transforming growth factor beta 2 (TGFβ2) on the progression of gastric carcinoma. TGFβ2 expression on cancer-associated fibroblasts (CAFs) was significantly correlated with lymph node metastasis and vascular invasion, but not with the T factor. Five-year survival of patients with TGFβ2-high on cancer cells and -low on CAFs was significantly worse in compared to the other group TGFβ2 on cancer cells might stimulates the cancer proliferation and invasion, but not TGFβ2 on CAFs. TGFβ2 high on cancer cells and low on CAF or others might be a promising prognostic factor for patients with GC. |
| Publish Date |
2026-09-03 02:49 |
| Citation |
Imanishi D, Nishikubo H, Ma D, Sano T, Fan C, Sakuma T, Yashiro M. Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma. World J Biol Chem 2026; 17(3): 121664
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| URL |
https://www.wjgnet.com/1949-8454/full/v17/i3/121664.htm |
| DOI |
https://doi.org/10.4331/wjbc.121664 |
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