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Articles Published Processes
6/4/2026 7:37:46 AM | Browse: 0 | Download: 0
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Received |
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2026-03-30 07:30 |
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Peer-Review Started |
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2026-03-31 07:35 |
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First Decision by Editorial Office Director |
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2026-04-15 09:02 |
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Return for Revision |
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2026-04-15 09:02 |
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Revised |
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2026-05-03 18:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-25 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-25 06:06 |
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Articles in Press |
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2026-05-25 06:06 |
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Edit the Manuscript by Language Editor |
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2026-05-31 20:28 |
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Typeset the Manuscript |
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2026-06-02 09:48 |
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Publish the Manuscript Online |
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2026-06-04 07:37 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Doha Mohamed, Asmaa A Ramadan, Hoda B Mabrok and Ibrahim Hamed |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Doha Mohamed, PhD, Professor, Department of Nutrition and Food Science, Food Industries and Nutrition Institute, National Research Centre, 33 El Buhouth Street, Ad Doqi, Dokki, Cairo 12622, Al Qāhirah, Egypt. dohaabdomohamed@gmail.com |
| Key Words |
Phytosterols; Lipid metabolism; Cholesterol absorption; Molecular mechanisms; Inflammation; Oxidative stress; Metabolic disorders; Cardiovascular disease; Functional foods |
| Core Tip |
Phytosterols are well-established cholesterol-lowering agents, but emerging evidence highlights their broader biological roles. This review provides a comprehensive synthesis of molecular mechanisms underlying phytosterol action, including modulation of liver X receptors, peroxisome proliferator-activated receptors, and AMP-activated protein kinase signaling, membrane lipid organization, and gut microbiota-bile acid interactions. These integrated pathways contribute to improved lipid and glucose metabolism, reduced inflammation, and enhanced cardiometabolic health, supporting the potential of phytosterols as multifunctional dietary bioactives beyond lipid lowering. |
| Publish Date |
2026-06-04 07:37 |
| Citation |
Mohamed D, Ramadan AA, Mabrok HB, Hamed I. Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects. World J Biol Chem 2026; 17(2): 121685
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| URL |
https://www.wjgnet.com/1949-8454/full/v17/i2/121685.htm |
| DOI |
https://doi.org/10.4331/wjbc.v17.i2.121685 |
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