| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Minireviews |
| Article Title |
Depression in chronic kidney disease and dialysis: A psychonephrology narrative review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Monika Yadav, Adarsh Kumar, Abhinav Pandey, Swarndeep Singh, Rajesh Kumar, Himanshu Verma, Sanjiv Mahajan, Sourabh Sharma, Pallavi Prasad and Anupam Agarwal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Adarsh Kumar, Associate Professor, DM, MD, Department of Nephrology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Ansari Nagar West, Aurobindo Marg, Ring Road, New Delhi 110029, DL, India. adarshnephro081@gmail.com |
| Key Words |
Chronic kidney disease; Depression; Dialysis; Psychonephrology; Uremic toxins |
| Core Tip |
Depression is one of the most common yet under-recognized comorbidities in chronic kidney disease (CKD), especially among patients receiving maintenance dialysis. Overlapping somatic symptoms of uremia often complicate its diagnosis, leading to under detection and undertreatment. Beyond its profound impact on quality of life, depression is associated with poor treatment adherence, increased hospitalization, malnutrition, reduced dialysis adequacy, and higher mortality. Emerging evidence suggests that inflammation, neuroendocrine dysregulation, uremic toxin accumulation, and psychosocial stressors collectively contribute to its pathogenesis. This review highlights the epidemiology, mechanisms, diagnostic challenges, and clinical consequences of depression across the CKD spectrum, while emphasizing the evolving role of psychonephrology in integrating psychological and renal care. Early recognition and multidisciplinary management are essential to improving holistic outcomes in CKD patients. |
| Publish Date |
2026-08-13 07:25 |
| Citation |
Yadav M, Kumar A, Pandey A, Singh S, Kumar R, Verma H, Mahajan S, Sharma S, Prasad P, Agarwal A. Depression in chronic kidney disease and dialysis: A psychonephrology narrative review. World J Nephrol 2026; 15(3): 121696
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| URL |
https://www.wjgnet.com/2220-6124/full/v15/i3/121696.htm |
| DOI |
https://doi.org/10.5527/wjn.121696 |
