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Articles Published Processes
8/25/2026 6:38:35 AM | Browse: 4 | Download: 0
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Received |
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2026-04-01 03:44 |
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Peer-Review Started |
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2026-04-01 03:45 |
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First Decision by Editorial Office Director |
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2026-04-10 10:28 |
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Return for Revision |
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2026-04-10 10:28 |
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Revised |
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2026-04-25 06:07 |
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Publication Fee Transferred |
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2026-04-29 04:05 |
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Second Decision by Editor |
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2026-05-29 03:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-29 06:45 |
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Articles in Press |
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2026-05-29 06:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-17 00:39 |
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Publish the Manuscript Online |
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2026-08-25 06:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
OH-CATH30 targets CD40 to suppress NF-κB signaling and promote arachidonic acid metabolic reprogramming in acute pancreatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ke-Liang Li, Yue Zhao, Wei-Jie Shang, Qi-Hang Guo, Hai-Tao Liu, Ji-Yu Zhang, Xue-Lin Jia and Bing-Rong Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhongyuan Talent Program |
ZYYCYU202012113 |
| Key R&D Program of Henan Province |
231111311600 |
| Outstanding Foreign Scientist Studio Project of Henan Province |
GZS2020006 |
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| Corresponding Author |
Bing-Rong Liu, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. fccliubr@zzu.edu.cn |
| Key Words |
Acute pancreatitis; OH-CATH30; CD40; Nuclear factor-kappa B signaling; Macrophage polarization; Anti-inflammatory peptide; Arachidonic acid metabolism |
| Core Tip |
This study identifies CD40 as a pivotal therapeutic target in acute pancreatitis. The antimicrobial peptide OH-CATH30 binds to CD40 and suppresses the CD40-tumor necrosis factor receptor-associated factor 6-transforming growth factor beta-activated kinase 1-nuclear factor-kappa B signaling cascade. This inhibition drives macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype and corrects arachidonic acid metabolic dysregulation. These findings establish CD40 as a central node that links inflammatory signaling and metabolic reprogramming in acute pancreatitis. Thus, OH-CATH30 is a promising multi-functional therapeutic candidate for this devastating inflammatory disease. |
| Publish Date |
2026-08-25 06:38 |
| Citation |
Li KL, Zhao Y, Shang WJ, Guo QH, Liu HT, Zhang JY, Jia XL, Liu BR. OH-CATH30 targets CD40 to suppress NF-κB signaling and promote arachidonic acid metabolic reprogramming in acute pancreatitis. World J Gastroenterol 2026; 32(36): 121753
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i36/121753.htm |
| DOI |
https://doi.org/10.3748/wjg.121753 |
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