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Articles Published Processes
2/7/2015 9:38:00 AM | Browse: 1067 | Download: 1289
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Received |
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2014-06-25 19:17 |
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Peer-Review Started |
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2014-06-26 14:39 |
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To Make the First Decision |
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2014-07-10 17:20 |
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Return for Revision |
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2014-07-11 17:53 |
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Revised |
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2014-07-16 16:23 |
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Second Decision |
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2014-10-27 16:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-27 17:02 |
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Articles in Press |
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2014-10-27 17:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-24 20:17 |
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Publish the Manuscript Online |
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2015-02-07 09:38 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Review |
| Article Title |
ACE and ACE2 in kidney disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sonoo Mizuiri and Yasushi Ohashi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Toho University School of Medicine Research Foundation |
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| Corresponding Author |
Sonoo Mizuiri, MD, PhD, Department of Nephrology, Ichiyokai Harada Hospital, 7-10 Kairoyama-Cho, Saeki-Ku, Hiroshima-Shi 731-5134,
Japan. sm210@med.toho-u.ac.jp
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| Key Words |
Angiotensin-converting enzyme; Angiotensin-converting enzyme 2; Diabetic nephropathy; Kidney disease; Renin angiotensin system |
| Core Tip |
In the kidneys, angiotensin-converting enzyme 2 (ACE2) is expressed in the proximal tubules and less strongly in the glomeruli. The synthesis of inactive Ang 1-9 from angio-tensin?Ⅰ?(Ang?Ⅰ) and the catabolism of Ang Ⅱ to produce Ang 1-7 represent the main functions of ACE2. Ang 1-7 reduces vasoconstriction, water retention, salt intake, cell proliferation, and reactive oxygen stress, and also has a renoprotective effect. Thus, in the non-classical renin angiotensin system the ACE2-Ang 1-7-Mas axis counteracts the ACE-Ang Ⅱ-AT1 axis. This review examines recent human and animal studies about ACE and ACE2 expression in various renal diseases.
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| Publish Date |
2015-02-07 09:38 |
| Citation |
Mizuiri S, Ohashi Y. ACE and ACE2 in kidney disease. World J Nephrol 2015; 4(1): 74-82 |
| URL |
http://www.wjgnet.com/2220-6124/full/v4/i1/74.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v4.i1.74 |
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