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Articles Published Processes
10/20/2026 3:52:42 AM | Browse: 0 | Download: 0
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Received |
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2026-04-03 03:39 |
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Peer-Review Started |
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2026-04-03 03:41 |
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First Decision by Editorial Office Director |
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2026-05-09 10:39 |
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Return for Revision |
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2026-05-09 10:39 |
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Revised |
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2026-05-23 09:26 |
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Publication Fee Transferred |
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2026-05-25 09:27 |
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Second Decision by Editor |
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2026-06-04 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-04 06:31 |
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Articles in Press |
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2026-06-04 06:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-20 03:50 |
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Publish the Manuscript Online |
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2026-10-20 03:52 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Cost-effectiveness of risk-stratified hepatocellular carcinoma screening using the age-male-albumin-bilirubin-platelets score-based stepwise enrichment approach in patients with cirrhosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Bo Zhang, Yu-Xuan Li, Wen-Di Zhang, Xian-Bin Hou, Rui Li, Ru-Yi Xia, Ming-Wang Shen, Zhuo-Ru Zou and Gui-Hua Zhuang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China National Science and Technology Major Project |
No. 2023ZD0501400 |
| National Natural Science Foundation of China |
No. 82304206 |
| China Postdoctoral Science Foundation |
No. BX20220254 |
| China Postdoctoral Science Foundation |
No. 2023M732773 |
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| Corresponding Author |
Gui-Hua Zhuang, PhD, Professor, Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, No. 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. zhuanggh@mail.xjtu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Screening; Age-male-albumin-bilirubin-platelets; Risk stratification; Cost-effectiveness; Cell-free deoxyribonucleic acid |
| Core Tip |
This study developed a Markov model to evaluate the cost-effectiveness of risk-stratified hepatocellular carcinoma screening using age-male-albumin-bilirubin-platelets score-based stepwise enrichment approach in compensated cirrhosis. A total of 600 screening strategies were evaluated, combining whether to apply stratification with different screening frequencies and methods. Stratified screening with ultrasonography (US) + alpha-fetoprotein (AFP) quarterly for high-risk and annually for low-risk groups, and screening with quarterly alternating US + AFP/gadoxetic-enhanced magnetic resonance imaging for high-risk and six-monthly US + AFP for low-risk groups, are the most cost-effective under the 1 × and 3 × gross domestic product thresholds, respectively. Furthermore, reducing cell-free DNA testing costs would boost the optimal strategies’ probability advantage, even if re-stratification is required more frequently. |
| Publish Date |
2026-10-20 03:52 |
| Citation |
Zhang YB, Li YX, Zhang WD, Hou XB, Li R, Xia RY, Shen MW, Zou ZR, Zhuang GH. Cost-effectiveness of risk-stratified hepatocellular carcinoma screening using the age-male-albumin-bilirubin-platelets score-based stepwise enrichment approach in patients with cirrhosis. World J Gastroenterol 2026; 32(46): 121840
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i46/121840.htm |
| DOI |
https://doi.org/10.3748/wjg.121840 |
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