| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Li Ma, Meng-Fei Hao, Mu-Xi Chen, Yu-Jie Lu, Jin-Ting Su, Shu Tong, Jia-Wei Wang, Xin Li, Ling-Yu Wei, Wei-Wei Wang, Xiao-Xuan Duan and Jin-Sheng Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Technology Commission Foundation of Shanxi Province |
202303021221181 |
| Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College |
HPYJ202512 |
| Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College |
HPYJ202215 |
| Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College |
HPYJ202223 |
| Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province (Key Laboratory of Esophageal Cancer Basic Research and Clinical Transformation, Heping Hospital Affiliated to Changzhi Medical College) |
2020SYS22 |
| the Changzhi Esophageal Cancer Research and Transformation Technology Innovation Center |
2022cx003 |
|
| Corresponding Author |
Jin-Sheng Wang, Department of Pathology, HePing Hospital Affiliated to Changzhi Medical College, No. 110, South Yan'an Road, Luzhou District, Changzhi City, Shanxi Province, P.R. China, Changzhi 046000, Shanxi Province, China. wjsczmc@163.com |
| Key Words |
Esophageal squamous cell carcinoma; CHMP2A; Prognosis; Proliferation; Angiogenesis |
| Core Tip |
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a poor prognosis. This study revealed that CHMP2A is significantly upregulated in ESCC tissues and cell lines, and its high expression predicts poor survival in ESCC patients. Functional assays demonstrated that CHMP2A promotes ESCC cell proliferation, invasion, migration, and tumor angiogenesis. Our findings identify CHMP2A as a novel prognostic biomarker in ESCC, potentially informing new strategies for its diagnosis and treatment. |
| Publish Date |
2026-10-09 08:15 |
| Citation |
Ma LL, Hao MF, Chen MX, Lu YJ, Su JT, Tong S, Wang JW, Li X, Wei LY, Wang WW, Duan XX, Wang JS. CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression. World J Gastrointest Oncol 2026; 18(10): 121843
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i10/121843.htm |
| DOI |
https://doi.org/10.4251/wjgo.121843 |
