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Articles Published Processes
9/7/2014 1:30:00 PM | Browse: 1518 | Download: 2133
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Received |
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2014-06-26 13:36 |
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Peer-Review Started |
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2014-06-26 13:36 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-07-09 13:11 |
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Revised |
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2014-07-18 00:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-07-30 10:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-07-30 10:27 |
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Articles in Press |
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2014-07-30 10:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-19 15:19 |
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Publish the Manuscript Online |
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2014-09-07 13:31 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Frontier |
| Article Title |
Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tony Trang, Johanna Chan and David Y Graham |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service which funds the Texas Medical Center Digestive Diseases Center |
DK067366 |
| The Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service which funds the Texas Medical Center Digestive Diseases Center |
DK56338 |
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| Corresponding Author |
David Y Graham, MD, Professor, Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, United States. dgraham@bcm.edu |
| Key Words |
Pancreatic insufficiency; Pancreatic enzyme replacement therapy; Lipase; Clinical trials; Steatorrhea; Fat malabsorption; Chronic pancreatitis |
| Core Tip |
In the last two decades, a number of studies comparing pancreatic enzymes and placebo have confirmed that pancreatic enzymes are superior to placebo for treatment of pancreatic malabsorption. While many patients achieved a satisfactory clinical response, individualization is often needed. Studies conclusively show that dose escalation is not a reliable method of obtaining further improvements and instead results in increased costs. Here, we describe alternate strategies for obtaining a satisfactory clinical response including changing to, or adding, a different product, adding non-enteric coated enzymes, use of antisecretory drugs and/or antacids, and changing the timing of enzyme administration. |
| Publish Date |
2014-09-07 13:31 |
| Citation |
Trang T, Chan J, Graham DY. Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century. World J Gastroenterol 2014; 20(33): 11467-11485
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| URL |
http://www.wjgnet.com/1007-9327/full/v20/i33/11467.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i33.11467 |
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