Publication Name	World Journal of Gastroenterology
Manuscript ID	12193
Country	United States

Received	2014-06-26 13:36
Peer-Review Started	2014-06-26 13:36
To Make the First Decision	2014-07-09 12:20
Return for Revision	2014-07-09 13:11
Revised	2014-07-18 00:00
Second Decision	2014-07-30 10:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-30 10:27
Articles in Press	2014-07-30 10:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-19 15:19
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century
Manuscript Source	Invited Manuscript
All Author List	Tony Trang, Johanna Chan and David Y Graham
Funding Agency and Grant Number	Funding Agency Grant Number The Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service which funds the Texas Medical Center Digestive Diseases Center DK067366 The Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service which funds the Texas Medical Center Digestive Diseases Center DK56338
Corresponding Author	David Y Graham, MD, Professor, Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, United States. dgraham@bcm.edu
Key Words	Pancreatic insufficiency; Pancreatic enzyme replacement therapy; Lipase; Clinical trials; Steatorrhea; Fat malabsorption; Chronic pancreatitis
Core Tip	In the last two decades, a number of studies comparing pancreatic enzymes and placebo have confirmed that pancreatic enzymes are superior to placebo for treatment of pancreatic malabsorption. While many patients achieved a satisfactory clinical response, individualization is often needed. Studies conclusively show that dose escalation is not a reliable method of obtaining further improvements and instead results in increased costs. Here, we describe alternate strategies for obtaining a satisfactory clinical response including changing to, or adding, a different product, adding non-enteric coated enzymes, use of antisecretory drugs and/or antacids, and changing the timing of enzyme administration.
Publish Date	2014-09-07 13:31
Citation	Trang T, Chan J, Graham DY. Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century. World J Gastroenterol 2014; 20(33): 11467-11485
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11467.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11467

Full Article (PDF)	WJG-20-11467.pdf
Full Article (Word)	WJG-20-11467.doc
Manuscript File	12193-Review.doc
Answering Reviewers	12193-Answering reviewers.pdf
Copyright License Agreement	12193-Copyright assignment.pdf
Peer-review Report	12193-Peer review.pdf
Scientific Misconduct Check	12193-CorssCheck.jpg
Scientific Editor Work List	12193-Scientific editor work list.pdf