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Articles Published Processes
9/28/2026 8:29:04 AM | Browse: 0 | Download: 0
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Received |
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2026-04-07 03:11 |
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Peer-Review Started |
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2026-04-07 03:20 |
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First Decision by Editorial Office Director |
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2026-04-28 02:44 |
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Return for Revision |
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2026-04-28 02:44 |
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Revised |
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2026-06-01 14:07 |
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Publication Fee Transferred |
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2026-06-07 14:46 |
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Second Decision by Editor |
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2026-06-23 02:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-23 05:37 |
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Articles in Press |
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2026-06-23 05:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-29 03:45 |
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Publish the Manuscript Online |
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2026-09-28 08:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Bridge of imbalance: How does the brain-gut axis act as a catalyst for gastrointestinal tumors in aging
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Xu, Cheng-Kang Qu, Ling-Ling Bao, Yu-Xuan Zhang, Wen-Juan Wang and Ying-Quan Ye |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wen-Juan Wang, Department of Hematology and Oncology, Beilun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 1288 East Lushan Road, Beilun District, Ningbo 315800, Zhejiang Province, China. wwjwjbwsy@163.com |
| Key Words |
Brain-gut axis; Aging; Gastrointestinal tumors; Gut microbiota; Central nervous system |
| Core Tip |
Aging remodels the brain-gut axis, creating a catalyst for gastrointestinal tumors. Key mechanisms include gut microbiota dysbiosis, neurotransmitter imbalance (e.g., 5-hydroxytryptamine, norepinephrine), neuroendocrine dysregulation, inflammaging, and circadian rhythm disruption. These factors remodel the tumor microenvironment, promote chronic inflammation, and drive tumorigenesis. Targeting the gut microbiota, neurotransmitter pathways, and circadian clocks offers emerging therapeutic strategies for aging-related gastrointestinal cancers. |
| Publish Date |
2026-09-28 08:29 |
| Citation |
Xu X, Qu CK, Bao LL, Zhang YX, Wang WJ, Ye YQ. Bridge of imbalance: How does the brain-gut axis act as a catalyst for gastrointestinal tumors in aging. World J Gastroenterol 2026; 32(43): 121944
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i43/121944.htm |
| DOI |
https://doi.org/10.3748/wjg.121944 |
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