Publication Name	World Journal of Diabetes
Manuscript ID	12195
Country	Türkiye

Received	2014-06-27 13:33
Peer-Review Started	2014-06-28 17:31
To Make the First Decision	2014-08-14 14:37
Return for Revision	2014-08-18 10:13
Revised	2014-09-04 20:44
Second Decision	2014-10-10 18:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-10 18:22
Articles in Press	2014-10-10 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-13 23:04
Typeset the Manuscript	2014-11-26 17:39
Publish the Manuscript Online	2014-12-13 19:01

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Sirtuins as novel players in the pathogenesis of diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Kultigin Turkmen, Ali Karagoz and Adem Kucuk
Funding Agency and Grant Number
Corresponding Author	Kultigin Turkmen, MD, Associate Professor, Head, Division of Nephrology, Department of Internal Medicine, Erzincan University, Başbağlar Mah., Terzibaba Cd, 24000 Erzincan, Turkey. mdkt2010@yahoo.com
Key Words	Diabetes mellitus; Sirtuins; Hyperglycemia; Hyperlipidemia; Resveratrol
Core Tip	Diabetes mellitus has been accepted as an epidemic worldwide during the last two decades. Despite the diagnostic tools and therapeutic approaches, the pathophysiology of this metabolic disorder and cellular defensive mechanisms are unknown. The maintenance of cellular homeostasis requires a well-organized network between glucose, amino acid and lipid metabolism. Sirtuins are a group of NAD+ dependent proteins that are involved in cellular homeostasis due to their deacetylating activity. Of these, sirtuin 1, -3 and -4 have been the most extensively investigated. In the present review, we aimed to discuss the role of associated sirtuins in glucose and lipid metabolism and in the pathogenesis and treatment of diabetes mellitus.
Publish Date	2014-12-13 19:01
Citation	Turkmen K, Karagoz A, Kucuk A. Sirtuins as novel players in the pathogenesis of diabetes mellitus. World J Diabetes 2014; 5(6): 894-900
URL	http://www.wjgnet.com/1948-9358/full/v5/i6/894.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i6.894

Full Article (PDF)	WJD-5-894.pdf
Full Article (Word)	WJD-5-894.doc
Manuscript File	12195-Review.doc
Answering Reviewers	12195-Answering reviewers.pdf
Copyright License Agreement	12195-Copyright assignment.pdf
Peer-review Report	12195-Peer review(s).pdf
Scientific Misconduct Check	12195-CrossCheck.jpg
Scientific Editor Work List	12195-Scientific editor work list.pdf