Publication Name	World Journal of Gastroenterology
Manuscript ID	12196
Country	China

Received	2014-06-27 09:05
Peer-Review Started	2014-06-27 10:09
To Make the First Decision	2014-08-15 12:17
Return for Revision	2014-08-20 13:07
Revised	2014-08-27 12:32
Second Decision	2014-09-30 10:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-30 10:32
Articles in Press	2014-09-30 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-11-10 20:10
Typeset the Manuscript	2015-01-23 15:36
Publish the Manuscript Online	2015-02-09 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	HIF-1a -1790G>A polymorphism significantly increases the risk of digestive tract cancer: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao Sun, Ying-Di Liu, Wei Gao, Shao-Hua Shen and Meng Li
Funding Agency and Grant Number
Corresponding Author	Ying-Di Liu, MD, PhD, Department of Gastroenterology, Hainan Branch of PLA General Hospital, Haitangwan, Sanya 572000, Hainan Province, China. liuyingti@yeah.net
Key Words	Hypoxia-inducible factor-1; Digestive tract cancer; Polymorphisms; Cancer risk; Meta-analysis
Core Tip	The functional polymorphisms of hypoxia-inducible factor-1? (HIF-1?) (-1772C>T and -1790G>A) have been extensively investigated; however, the relationship between HIF-1? polymorphisms and digestive tract cancer has remained unclear. In this work, we found that the HIF-1? -1772C>T polymorphism was not associated with the overall risk of developing digestive tract cancer (dominant comparison, OR: 1.156; 95%CI: 0.839-1.593; Pheterogeneity = 0.007). However, the variant -1790A allele significantly increased the risk of digestive tract cancer (OR: 3.252; 95%CI: 1.661-6.368; Pheterogeneity < 0.001).
Publish Date	2015-02-09 17:58
Citation	Sun X, Liu YD, Gao W, Shen SH, Li M. HIF-1 -1790G>A polymorphism significantly increases the risk of digestive tract cancer: A meta-analysis. World J Gastroenterol 2015; 21(5): 1641-1649
URL	http://www.wjgnet.com/1007-9327/full/v21/i5/1641.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i5.1641

Full Article (PDF)	WJG-21-1641.pdf
Full Article (Word)	WJG-21-1641.doc
Manuscript File	12196-Review.docx
Answering Reviewers	12196-Answering reviewers.pdf
Copyright License Agreement	12196-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12196-Language certificate.pdf
Peer-review Report	12196-Peer review.pdf
Scientific Misconduct Check	12196-CorssCheck.jpg
Scientific Editor Work List	12196-Scientific editor work list.pdf