BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/29/2026 7:19:31 AM | Browse: 2 | Download: 0
 |
Received |
|
2026-04-24 10:42 |
|
Peer-Review Started |
|
2026-04-24 10:43 |
|
First Decision by Editorial Office Director |
|
2026-05-20 08:28 |
|
Return for Revision |
|
2026-05-20 08:28 |
|
Revised |
|
2026-06-10 11:10 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-09-10 02:43 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-09-10 09:16 |
|
Articles in Press |
|
2026-09-10 09:16 |
|
Edit the Manuscript by Language Editor |
|
2026-09-26 19:26 |
|
Typeset the Manuscript |
|
2026-10-14 01:26 |
|
Publish the Manuscript Online |
|
2026-10-29 07:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Serum proprotein convertase subtilisin/kexin type 9 levels correlate with depression severity in post-stroke patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Yan Song, Yue Yang, Xiao-Yang Sun, Meng-Jun Zhang and Shu-Gen Wang |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Hong-Yan Song, Department of Pharmacy, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou 061000, Hebei Province, China. 963809412@qq.com |
| Key Words |
Post-stroke depression; Evolocumab; Proprotein convertase subtilisin/kexin type 9; Statin; Depression scores; Biomarkers; Neuroinflammation |
| Core Tip |
This study shows that evolocumab combined with statin therapy can significantly decrease serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels, and it has a positive effect on depression in patients with post-stroke depression. This displays a strong correlation (r = 0.652), indicating PCSK9 as a potential biomarker of depression severity. Combination therapy was superior, with a 73.4% response rate vs 48.4% monotherapy (P < 0.05), leading to reduced neuroinflammation and improved cognition. Our data support the use of PCSK9-targeted therapy as a novel adjunctive treatment strategy in post-stroke depression. |
| Publish Date |
2026-10-29 07:19 |
| Citation |
Song HY, Yang Y, Sun XY, Zhang MJ, Wang SG. Serum proprotein convertase subtilisin/kexin type 9 levels correlate with depression severity in post-stroke patients. World J Psychiatry 2026; 16(11): 122026
|
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i11/122026.htm |
| DOI |
https://doi.org/10.5498/wjp.122026 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
