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6/16/2026 9:18:24 AM | Browse: 0 | Download: 0
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Received |
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2026-04-08 03:28 |
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Peer-Review Started |
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2026-04-08 03:28 |
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First Decision by Editorial Office Director |
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2026-04-23 05:03 |
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Return for Revision |
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2026-04-23 05:03 |
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Revised |
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2026-05-02 06:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-11 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-11 06:48 |
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Articles in Press |
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2026-06-11 06:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-11 10:17 |
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Publish the Manuscript Online |
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2026-06-16 09:18 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Gut barrier dysfunction and multidrug-resistant bacterial translocation in adult critical illness: Mechanistic insights from a systematic review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shree V Dhotre, Pradnya S Dhotre, Sachin S Mumbre and Basavraj S Nagoba |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. basavraj.nagoba@mimsr.edu.in |
| Key Words |
Gut barrier dysfunction; Tight junctions; Multidrug-resistant bacteria; Carbapenem-resistant Enterobacteriaceae; Bacterial translocation; Critical illness; Sepsis; Gut microbiome dysbiosis |
| Core Tip |
Intestinal colonization with multidrug-resistant organisms often precedes bloodstream infection in critically ill adults. Findings from clinical cohorts, microbiome analyses, and biomarker studies indicate that disruption of epithelial barrier integrity and loss of microbiome-mediated colonization resistance may increase the risk of systemic infection. However, most available evidence is observational and remains susceptible to confounding, particularly from antibiotic exposure, illness severity, and intensive care units-related factors. This PRISMA-compliant systematic review brings together mechanistic and clinical evidence, with careful appraisal of study quality, and identifies gut barrier dysfunction as a plausible - though not definitively causal - contributor to antimicrobial resistance-associated infections, highlighting important directions for future research. |
| Publish Date |
2026-06-16 09:18 |
| Citation |
Dhotre SV, Dhotre PS, Mumbre SS, Nagoba BS. Gut barrier dysfunction and multidrug-resistant bacterial translocation in adult critical illness: Mechanistic insights from a systematic review. World J Gastrointest Pathophysiol 2026; 17(2): 122029
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| URL |
https://www.wjgnet.com/2150-5330/full/v17/i2/122029.htm |
| DOI |
https://doi.org/10.4291/wjgp.v17.i2.122029 |
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