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Articles Published Processes
7/24/2026 10:16:20 AM | Browse: 2 | Download: 0
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Received |
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2026-04-08 01:38 |
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Peer-Review Started |
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2026-04-08 01:40 |
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First Decision by Editorial Office Director |
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2026-04-23 10:10 |
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Return for Revision |
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2026-04-24 12:19 |
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Revised |
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2026-05-13 07:42 |
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Publication Fee Transferred |
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2026-05-20 06:19 |
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Second Decision by Editor |
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2026-06-17 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-18 08:26 |
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Articles in Press |
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2026-06-18 08:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-21 00:57 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Efficacy and safety of cell-based regenerative therapies for fistula-related diseases: An umbrella review of systematic reviews
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Long Duan, Yong-Hao Wen, Si-Ai Chen, Ru Nie, Ming-Quan Pang, Man-Jun Deng, Zhi-Xin Wang and Hai-Ning Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fourth “Qinghai Scholar” Program |
2025-qhxz-fhn |
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| Corresponding Author |
Hai-Ning Fan, Chief Physician, Full Professor, PhD, Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. fanhaining@medmail.com.cn |
| Key Words |
Regenerative therapy; Mesenchymal stem cells; Platelet-rich plasma; Perianal fistulas; Fistulizing Crohn’s disease |
| Core Tip |
This umbrella review demonstrates that mesenchymal stem cells (MSCs) based regenerative therapy is associated with meaningful improvements in healing and remission in perianal fistulas and fistulizing Crohn’s disease. The most consistent benefits were observed with adipose-derived, allogeneic, and locally injected MSC. MSC therapy was generally well tolerated, with no increase in overall adverse events and potential reduction in serious adverse events. Among currently studied regenerative approaches, MSC appears to be the most promising option for fistula-related diseases. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Duan YL, Wen YH, Chen SA, Nie R, Pang MQ, Deng MJ, Wang ZX, Fan HN. Efficacy and safety of cell-based regenerative therapies for fistula-related diseases: An umbrella review of systematic reviews. World J Stem Cells 2026; 18(7): 122048
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/122048.htm |
| DOI |
https://doi.org/10.4252/wjsc.122048 |
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