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Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 122115
Country India
Received
2026-04-10 06:21
Peer-Review Started
2026-04-10 06:22
First Decision by Editorial Office Director
2026-04-29 10:34
Return for Revision
2026-04-29 10:34
Revised
2026-05-25 01:08
Publication Fee Transferred
Second Decision by Editor
2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-12 06:33
Articles in Press
2026-06-12 06:33
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-03 07:40
Publish the Manuscript Online
2026-09-08 03:16
ISSN 2150-5330 (online)
Open Access Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Pathophysiological management of gastric varices: From hemodynamics to targeted therapies
Manuscript Source Invited Manuscript
All Author List Suprabhat Giri, Ranjan K Patel, Tara Prasad Tripathy, Dibya Lochan Praharaj and Radhika Chavan
ORCID
Author(s) ORCID Number
Suprabhat Giri http://orcid.org/0000-0002-9626-5243
Ranjan K Patel http://orcid.org/0000-0003-4780-5810
Tara Prasad Tripathy http://orcid.org/0000-0003-3763-9089
Dibya Lochan Praharaj http://orcid.org/0000-0002-4995-1611
Radhika Chavan http://orcid.org/0000-0002-5363-597X
Funding Agency and Grant Number
Corresponding Author Suprabhat Giri, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Kushabhadra Campus, 5, KIIT Rd, Patia, Bhubaneswar 751024, Odisha, India. supg19167@gmail.com
Key Words Gastric varices; Portal hypertension; Balloon-occluded retrograde transvenous obliteration; Transjugular intrahepatic portosystemic shunt; Endoscopic ultrasound
Core Tip Gastric varices require a pathophysiology-driven management strategy distinct from esophageal varices. Therapy selection should be guided by hemodynamic classification, integrating Sarin (location), Kiyosue and Saad-Caldwell (inflow-outflow anatomy), and clinical factors. Shunt-dominant varices are best treated with Balloon-occluded retrograde transvenous obliteration or its variants, while pressure-dominant disease requires a transjugular intrahepatic portosystemic shunt for global decompression. Endoscopic ultrasound-guided coil ± glue therapy offers precise, flow-directed treatment in complex anatomy or high-risk patients. Clinical modifiers such as hepatic encephalopathy, ascites, liver reserve, and portal vein patency are critical in decision-making. A multidisciplinary approach combining endoscopic, radiologic, and surgical modalities is essential for optimal and durable outcomes.
Publish Date 2026-09-08 03:16
Citation

Giri S, Patel RK, Tripathy TP, Praharaj DL, Chavan R. Pathophysiological management of gastric varices: From hemodynamics to targeted therapies. World J Gastrointest Pathophysiol 2026; 17(3): 122115

URL https://www.wjgnet.com/2150-5330/full/v17/i3/122115.htm
DOI https://doi.org/10.4291/wjgp.122115
Full Article (PDF) WJGP-17-122115-with-cover.pdf
Manuscript File 122115_Auto_Edited_005404.docx
Answering Reviewers 122115-answering-reviewers.pdf
Audio Core Tip 122115-audio.m4a
Conflict-of-Interest Disclosure Form 122115-conflict-of-interest-statement.pdf
Copyright License Agreement 122115-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 122115-non-native-speakers.pdf
Peer-review Report 122115-peer-reviews.pdf
Scientific Misconduct Check 122115-scientific-misconduct-check.png
CrossCheck Report 122115-crosscheck-report.pdf