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Articles Published Processes
9/3/2026 2:08:39 AM | Browse: 0 | Download: 0
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Received |
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2026-04-10 06:21 |
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Peer-Review Started |
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2026-04-10 06:22 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 01:54 |
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Revised |
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2026-07-20 07:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-18 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-18 09:30 |
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Articles in Press |
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2026-08-18 09:30 |
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Edit the Manuscript by Language Editor |
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2026-08-26 09:22 |
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Typeset the Manuscript |
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2026-08-28 05:57 |
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Publish the Manuscript Online |
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2026-09-03 02:08 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Interleukin-6 and tumor necrosis factor-α in osteoimmunology: Aging, and anticytokine therapies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arunagiri Gunasekar, Naveen Jeyaraman, Sneha Babu Chitra, Vathani Yudakar, Sanjeevi Bharadwaj, Sathish Muthu and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, Associate Professor, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Receptor activator of NF-kappa B ligand/osteoprotegerin axis; Janus kinase/nuclear factor kappa B; Osteoprotegerin; Inflammaging; Senolytics |
| Core Tip |
Interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) are important cytokines that have been implicated in the pathogenesis of bone loss by means of an imbalance of receptor activator of NF-kappa B ligand/osteoprotegerin, nuclear factor kappa B activation, and osteoclast encouragement. They are aggravated by inflammatory bone diseases and osteoporosis caused by inflammaging and senescence-associated secretory phenotype. Their crosstalk promotes bone resorption by dysregulating immune cells. Anti-TNF-α and anti-IL-6 treatments normalize bone homeostasis, and observational data suggest a lower reduction in fracture occurrence, an estimate that should be interpreted cautiously given its non-randomized basis. These novel methods include senolytics, Janus kinase, and cytokine-based precision medicine. |
| Publish Date |
2026-09-03 02:08 |
| Citation |
Gunasekar A, Jeyaraman N, Chitra SB, Yudakar V, Bharadwaj S, Muthu S, Jeyaraman M. Interleukin-6 and tumor necrosis factor-α in osteoimmunology: Aging, and anticytokine therapies. World J Transl Med 2026; 12(3): 122119
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| URL |
https://www.wjgnet.com/2220-6132/full/v12/i3/122119.htm |
| DOI |
https://doi.org/10.5528/wjtm.122119 |
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