| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Impact of Limosilactobacillus reuteri DSM 17938 on early-life gut microbial diversity
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tanawan Noicharoen, Duc Long Tran, Areewan Soontornsook, Chonnikant Visuthranukul, Thanita Thammarakcharoen, Pavit Klomkliew, Suthida Visedthorn, Kittima Phutthawong, Sunchai Payungporn and Palittiya Sintusek |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ratchadapiseksompotch Fund |
No. 67/026 |
| Ratchadapiseksompotch Fund |
No. 67/027 |
| Thailand Science research and Innovation Fund Chulalongkorn University |
No. HEA_FF_69_225_3000_031 |
| the Second Century Fund (C2F) from Chulalongkorn University |
|
|
| Corresponding Author |
Palittiya Sintusek, Associate Professor, MD, PhD, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Division of Gastroenterology and Hepatology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873 Rama IV, Pathumwan, Bangkok 10330, Thailand. palittiya.s@chula.ac.th |
| Key Words |
Gut microbiota; Limosilactobacillus reuteri DSM 17938; Probiotics; Infant; Functional gastrointestinal disorder |
| Core Tip |
While Limosilactobacillus reuteri (L. reuteri) DSM 17938 has demonstrated benefits in several pediatric gastrointestinal conditions, its effects on gut microbiota modulation in exclusively breastfed infants remain unclear. In this prospective sub-study of a randomized controlled trial, L. reuteri DSM 17938 supplementation during the first two months of life was associated with an increased Bifidobacterium abundance and, independently of the delivery modes, higher Parabacteroides and Hungatella hathewayi were the most distinctive species identified in vaginally- and cesarean-delivered infants, respectively. L. reuteri DSM 17938 administration induced only modest and transient microbiota changes, with no evidence of sustained colonization. |
| Publish Date |
2026-10-09 04:02 |
| Citation |
Noicharoen T, Tran DL, Soontornsook A, Visuthranukul C, Thammarakcharoen T, Klomkliew P, Visedthorn S, Phutthawong K, Payungporn S, Sintusek P. Impact of Limosilactobacillus reuteri DSM 17938 on early-life gut microbial diversity. World J Clin Pediatr 2026; 15(4): 122122
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i4/122122.htm |
| DOI |
https://doi.org/10.5409/wjcp.122122 |
