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Publication Name World Journal of Biological Chemistry
Manuscript ID 12213
Country of Manuscript Source Italy
Received
2014-06-28 14:17
Peer-Review Started
2014-06-28 19:13
To Make the First Decision
2014-07-18 12:34
Return for Revision
2014-07-18 16:55
Revised
2014-08-01 15:40
Second Decision
2014-09-10 13:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-10 13:57
Articles in Press
2014-09-10 13:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-20 09:13
Publish the Manuscript Online
2014-12-02 12:16
ISSN 1949-8454 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Cell Biology
Manuscript Type Autobiography
Article Title Short- and long-term effects of silver nanoparticles on human microvascular endothelial cells
Manuscript Source Invited Manuscript
All Author List Sara Castiglioni, Clelia Caspani, Alessandra Cazzaniga and Jeanette AM Maier
Funding Agency and Grant Number
Corresponding author Jeanette AM Maier, MD, Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco, Università di Milano, Via GB Grassi, 74, Milano 20157, Italy. jeanette.maier@unimi.it
Keywords Endothelial cells; Nanoparticles; Genotoxicity; Cytotoxicity; Angiogenesis
Core Tip We studied the sensitivity to silver nanoparticles of microvascular endothelial cells, which are responsible for tissue homeostasis and fundamental in angiogenesis. Silver nanoparticles are cytotoxic and lead to membrane leakage. Cytotoxicity is not prevented by the antioxidants Trolox, N-acetyl-L-cysteine or apocynin. Silver nanoparticles also induce DNA damage as demonstrated by comet assay. When exposed to sublethal concentrations of silver nanoparticles for long times, the cells remain viable but are growth retarded. Interestingly, removal of silver nanoparticle rescue cell growth, suggesting that no permanent modifications occur. Silver nanoparticles are cytotoxic and genotoxic also for endothelial progenitors, which contribute to angiogenesis.
Publish Date 2014-12-02 12:16
Citation Castiglioni S, Caspani C, Cazzaniga A, Maier JAM. Short- and long-term effects of silver nanoparticles on human microvascular endothelial cells. World J Biol Chem 2014; 5(4): 457-464
Url http://www.wjgnet.com/1949-8454/full/v5/i4/457.htm
DOI http://dx.doi.org/10.4331/wjbc.v5.i4.457
Full Article (PDF) WJBC-5-457.pdf
Full Article (Word) WJBC-5-457.doc
Manuscript File 12213-Review.doc
Answering Reviewers 12213-Answering reviewers.pdf
Copyright License Agreement 12213-Copyright assignment.pdf
Peer-review Report 12213-Peer review(s).pdf
Scientific Misconduct Check 12213-CrossCheck.jpg
Scientific Editor Work List 12213-Scientific editor work list.pdf