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10/9/2026 4:02:26 AM | Browse: 9 | Download: 97
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Received |
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2026-04-13 05:50 |
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Peer-Review Started |
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2026-04-13 05:51 |
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First Decision by Editorial Office Director |
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2026-04-29 10:35 |
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2026-04-29 10:35 |
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Revised |
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2026-05-18 13:30 |
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Second Decision by Editor |
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2026-06-04 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-04 05:19 |
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Articles in Press |
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2026-06-04 05:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-15 00:36 |
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Publish the Manuscript Online |
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2026-10-09 04:02 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Non-nutritional rickets: Approach, precision medicine, and outcomes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pratyush Prateek Pathak and Sayantan Ray |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sayantan Ray, Assistant Professor, Department of Endocrinology, All India Institute of Medical Sciences, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. sayantan.ray30@gmail.com |
| Key Words |
Calcium; Vitamin D; Calciopenic rickets; Hypophosphatemic rickets; Algorithm; Fibroblast growth factor 23 |
| Core Tip |
Non-nutritional rickets represent a heterogeneous group of disorders. Presentation before 6 months or after 2 years of age, stigmata of specific systemic illnesses, and lack of response to oral calcium and vitamin D should raise clinical suspicion. A systematic diagnostic algorithm can guide evaluation. Parathyroid hormone may serve as a useful initial biochemical discriminator between calciopenic and hypophosphatemic rickets. Fibroblast growth factor 23 assays help distinguish fibroblast growth factor 23-dependent and independent hypophosphatemic rickets subtypes. Levels of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D help sub-classify heritable forms of calciopenic rickets. Several entities require molecular techniques for diagnostic confirmation, enabling precision medicine and genetic counselling. |
| Publish Date |
2026-10-09 04:02 |
| Citation |
Pathak PP, Ray S. Non-nutritional rickets: Approach, precision medicine, and outcomes. World J Clin Pediatr 2026; 15(4): 122166
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i4/122166.htm |
| DOI |
https://doi.org/10.5409/wjcp.122166 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
