Publication Name	World Journal of Rheumatology
Manuscript ID	12218
Country	Brazil

Received	2014-06-29 14:46
Peer-Review Started	2014-06-29 16:00
To Make the First Decision	2014-09-16 10:51
Return for Revision	2014-09-18 08:34
Revised
Second Decision	2014-11-03 17:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-03 17:16
Articles in Press	2014-11-03 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-30 14:33
Publish the Manuscript Online	2015-07-08 09:04

ISSN	2220-3214 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Rheumatology
Manuscript Type	Systematic Reviews
Article Title	What is the best biological treatment for rheumatoid arthritis? A systematic review of effectiveness
Manuscript Source	Invited Manuscript
All Author List	Jéssica Barreto dos Santos, Juliana de Oliveira Costa, Haliton Alves de Oliveira Junior, Lívia Lovato Pires Lemos, Vânia Eloisa de Araújo, Marina Amaral de Ávila Machado, Alessandra Maciel Almeida, Francisco de Assis Acurcio and Juliana Alvares
Funding Agency and Grant Number	Funding Agency Grant Number Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
Corresponding Author	Toshiyuki Yamamoto, MD, PhD, Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima 960-1295, Japan. toyamade@fmu.ac.jp
Key Words	Systematic review; Meta-analysis; Effectiveness; Biological disease-modifying antirheumatic drugs; Rheumatoid arthritis
Core Tip	Rheumatoid arthritis is a chronic, progressive, systemic inflammatory disease that preferentially affects the synovial membranes of joints, eventually leading to bone and cartilage destruction. Its worldwide prevalence is estimated to be 0.3% to 1%. Observational studies could provide relevant information for deciding the choice of treatments, the elaboration of clinical protocols, and the formulation of health policies. The present systematic review of biological disease-modifying antirheumatic drugs included cohort observational studies that reported treatment results applied in real-life conditions; thus, these studies are able to fill in gaps in knowledge left by clinical trials.
Publish Date	2015-07-08 09:04
Citation	dos Santos JB, Costa JO, Oliveira Junior HA, Lemos LLP, Araújo VE, Machado MAÁ, Almeida AM, Acurcio FA, Alvares J. What is the best biological treatment for rheumatoid arthritis? A systematic review of effectiveness. World J Rheumatol 2015; 5(2): 108-126
URL	http://www.wjgnet.com/2220-3214/full/v5/i2/108.htm
DOI	http://dx.doi.org/10.5499/wjr.v5.i2.108

Full Article (PDF)	WJR-5-108.pdf
Full Article (Word)	WJR-5-108.doc
Manuscript File	12218-Review.doc
Answering Reviewers	12218-Answering reviewers.pdf
Copyright License Agreement	12218-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12218-Language certificate.pdf
Peer-review Report	12218-Peer review(s).pdf
Scientific Misconduct Check	12218-CrossCheck.jpg
Scientific Editor Work List	12218-Scientific editor work list.pdf