Publication Name	World Journal of Pharmacology
Manuscript ID	12221
Country	Ukraine

Received	2014-07-01 10:13
Peer-Review Started	2014-07-01 11:02
First Decision by Editorial Office Director
Return for Revision	2014-07-30 13:13
Revised	2014-08-07 21:56
Publication Fee Transferred
Second Decision by Editor	2014-10-29 17:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-10-29 18:54
Articles in Press	2014-10-29 18:54
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-28 17:53
Publish the Manuscript Online	2014-12-12 11:14

ISSN	2220-3192 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Mathematical & Computational Biology
Manuscript Type	Minireviews
Article Title	Pharmacophore approaches in protein kinase inhibitors design
Manuscript Source	Invited Manuscript
All Author List	Sergiy A Starosyla, Galyna P Volynets, Volodymyr G Bdzhola, Andriy G Golub and Sergiy M Yarmoluk
Funding Agency and Grant Number
Corresponding Author	Dr. Sergiy M Yarmoluk, Sci., Professor, Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03680 Kyiv, Ukraine. sergiy@yarmoluk.org.ua
Key Words	Protein kinase; Inhibitor; Pharmacophore model; Receptor-based method; Ligand-based method
Core Tip	In the following review, we summarize the published data on pharmacophore models for inhibitors of tyrosine protein kinases (EGFR, HER2, VEGFR, JAK2, JAK3, Syk, ZAP-70, Tie2) and inhibitors of serine/threonine kinases (Clk, Dyrk, Chk1, IKK2, CDK1, CDK2, PLK, JNK3, GSK3, mTOR, p38 MAPK, PKB). Here, we have described the achievements of pharmacophore modeling for protein kinase inhibitors, which provide key points for further application of generated pharmacophore hypotheses in virtual screening, de novo design and lead optimization.
Publish Date	2014-12-12 11:14
Citation	Starosyla SA, Volynets GP, Bdzhola VG, Golub AG, Yarmoluk SM. Pharmacophore approaches in protein kinase inhibitors design. World J Pharmacol 2014; 3(4): 162-173
URL	http://www.wjgnet.com/2220-3192/full/v3/i4/162.htm
DOI	http://dx.doi.org/10.5497/wjp.v3.i4.162

Full Article (PDF)	WJP-3-162.pdf
Full Article (Word)	WJP-3-162.doc
Manuscript File	12221-Review.docx
Answering Reviewers	12221-Answering reviewers.pdf
Copyright License Agreement	12221-Copyright assignment.pdf
Peer-review Report	12221-Peer review(s).pdf
Scientific Misconduct Check	12221-CrossCheck.jpg
Scientific Editor Work List	12221-Scientific editor work list.pdf