| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Effects of berberine-containing vs clarithromycin-containing quadruple therapy on intestinal microbiota during Helicobacter pylori eradication
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Teng-Wei Cai, Zhi-Kai Chen, Zi-Yan Lv, Wen-Jun Jiang, Ye-Yu Sun, Ling-Xiao Jin, Chen-Mei Xia, Qian-Qian Li and Xia Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Science and Technology Program of Traditional Chinese Medicine, China |
No. 2023ZL784 |
| Wenling Social Development Science and Technology Project, China |
No. 2024S00303 |
|
| Corresponding Author |
Xia Chen, Chief Physician, Department of Gastroenterology, The First People’s Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, No. 333 Chuan’an South Road, Chengxi Street, Wenling 317500, Zhejiang Province, China. werla@sina.com |
| Key Words |
Helicobacter pylori; Berberine; Clarithromycin; Intestinal flora; Bifidobacterium catenulatum; Blautia; Longicatena |
| Core Tip |
This study compares berberine and clarithromycin-based therapy for Helicobacter pylori (H. pylori) eradication. The two regimens have comparable H. pylori eradication efficacy (80.95% vs 75.00%). Berberine causes milder intestinal flora disturbance, maintains flora homeostasis, enriches beneficial bacteria, and reduces antibiotic resistance risk, serving as a promising alternative for H. pylori eradication, especially in antibiotic-resistant populations. |
| Publish Date |
2026-09-28 08:29 |
| Citation |
Cai TW, Chen ZK, Lv ZY, Jiang WJ, Sun YY, Jin LX, Xia CM, Li QQ, Chen X. Effects of berberine-containing vs clarithromycin-containing quadruple therapy on intestinal microbiota during Helicobacter pylori eradication. World J Gastroenterol 2026; 32(43): 122243
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i43/122243.htm |
| DOI |
https://doi.org/10.3748/wjg.122243 |
