BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/18/2026 3:51:53 AM | Browse: 1 | Download: 0
 |
Received |
|
2026-04-20 07:45 |
|
Peer-Review Started |
|
2026-04-20 07:46 |
|
First Decision by Editorial Office Director |
|
2026-05-26 05:12 |
|
Return for Revision |
|
2026-05-26 05:12 |
|
Revised |
|
2026-06-10 16:15 |
|
Publication Fee Transferred |
|
2026-06-11 12:25 |
|
Second Decision by Editor |
|
2026-07-01 02:34 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-07-01 08:45 |
|
Articles in Press |
|
2026-07-01 08:45 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-07 00:42 |
|
Publish the Manuscript Online |
|
2026-08-18 03:51 |
| ISSN |
1948-5182 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Long Huang, Cheng-Gui Wu, Teng-Fei Zhu, Qing-Lin Li, Qing-Sheng Yu, Qi Zhang and Yi Shen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Projects of Anhui Provincial Health Commission |
AHWJ2023A30146 |
| Scientific Research Projects in Anhui Provincial Colleges and Universities |
2024AH050959 |
| Anhui Provincial Natural Science Foundation |
2408085MH222 |
|
| Corresponding Author |
Long Huang, MD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. huanglong658@163.com |
| Key Words |
Liver fibrosis; STAT3/MYC/MCL-1 pathway; Network pharmacology; Single-cell RNA sequencing; Hepatic stellate cells |
| Core Tip |
This study comprehensively explored the pharmacological mechanism of a fixed Jianpi Huoxue Formula (FJHF). We integrated single-cell transcriptomics, clinical observations, and in vitro experiments to confirm that FJHF inhibits the STAT3/MYC/MCL-1 pathway, suppresses hepatic stellate cell activation, and ameliorates early biochemical abnormalities in liver fibrosis. |
| Publish Date |
2026-08-18 03:51 |
| Citation |
Huang L, Wu CG, Zhu TF, Li QL, Yu QS, Zhang Q, Shen Y. Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis. World J Hepatol 2026; 18(8): 122262
|
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i8/122262.htm |
| DOI |
https://doi.org/10.4254/wjh.122262 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
