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Articles Published Processes
9/4/2026 5:57:42 AM | Browse: 1 | Download: 0
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Received |
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2026-04-17 00:31 |
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Peer-Review Started |
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2026-04-22 08:59 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-17 08:23 |
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Revised |
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2026-07-01 05:55 |
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Publication Fee Transferred |
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2026-07-20 01:41 |
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Second Decision by Editor |
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2026-07-24 03:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-28 13:16 |
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Articles in Press |
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2026-07-28 13:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-25 07:58 |
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Publish the Manuscript Online |
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2026-09-04 05:57 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Targeting gut microbiota: Potential mechanisms in the pathogenesis of type 2 diabetes mellitus and emerging translational intervention strategies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Jian Xie, Miao Zhang, Wan-Ting Li, Wei-Ye Zhou, Hai-Bei Ma, Yu Xu and Li-Ming Bi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wuxi “Double Hundred” Young and Middle-aged Medical Top Talents Program |
No. BJ2023065 |
| Jiangsu Provincial Administration of Traditional Chinese Medicine |
No. ZZYB21 |
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| Corresponding Author |
Li-Ming Bi, PhD, Department of Traditional Chinese Medicine Classics, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, No. 8 Zhongnan West Road, Binhu District, Wuxi 214071, Jiangsu Province, China. biliming00@aliyun.com |
| Key Words |
Type 2 diabetes mellitus; Gut microbiota; Traditional Chinese medicine; Treatment; Metabolic diseases |
| Core Tip |
Increasing evidence indicates that gut microbiota plays a critical role in the development of type 2 diabetes mellitus (T2DM). Unlike previous reviews that primarily focus on microbial compositional alterations, this review highlights that functional dysregulation of the gut microbiota is the central driver of T2DM pathogenesis. We propose an integrated metabolic-immune-barrier-endocrine framework linking microbial metabolites, inflammation, intestinal barrier dysfunction, and endocrine signaling to glucose dysregulation. We further summarize emerging microbiota-targeted interventions and their translational potential for personalized T2DM management. |
| Publish Date |
2026-09-04 05:57 |
| Citation |
Xie FJ, Zhang M, Li WT, Zhou WY, Ma HB, Xu Y, Bi LM. Targeting gut microbiota: Potential mechanisms in the pathogenesis of type 2 diabetes mellitus and emerging translational intervention strategies. World J Diabetes 2026; 17(9): 122293
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i9/122293.htm |
| DOI |
https://doi.org/10.4239/wjd.122293 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
