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Articles Published Processes
9/24/2026 6:23:43 AM | Browse: 0 | Download: 0
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Received |
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2026-04-17 03:00 |
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Peer-Review Started |
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2026-04-17 03:01 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 08:33 |
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Revised |
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2026-07-10 19:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-17 08:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-15 09:17 |
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Articles in Press |
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2026-09-15 09:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-20 09:39 |
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Publish the Manuscript Online |
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2026-09-24 06:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Cancer stem cell plasticity drives therapy resistance in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Uğur Topal, Ahmet Gökhan Saritas and Cihan Zamur |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Uğur Topal, Assistant Professor, Chief, FACS, PhD, Department of Surgical Oncology, Cukurova University, Balcalı Mahallesi, Sarıçam, Adana 01000, Türkiye. sutopal2005@hotmail.com |
| Key Words |
Colorectal cancer; Cancer stem cells; Plasticity; Therapy resistance; Tumor microenvironment; Metastasis |
| Core Tip |
Cancer stem cells (CSCs) are major drivers of therapy resistance, recurrence, and metastasis in colorectal cancer. Increasing evidence indicates that CSC plasticity enables differentiated tumor cells to reacquire stem-like properties, thereby sustaining tumor heterogeneity and therapeutic failure. This review highlights the molecular mechanisms regulating CSC plasticity, including developmental signaling pathways, epigenetic reprogramming, metabolic adaptation, and tumor microenvironment interactions. It also discusses emerging therapeutic strategies targeting CSCs and their plasticity, emphasizing that simultaneous inhibition of stemness and phenotypic switching may improve long-term treatment outcomes. |
| Publish Date |
2026-09-24 06:23 |
| Citation |
Topal U, Saritas AG, Zamur C. Cancer stem cell plasticity drives therapy resistance in colorectal cancer. World J Stem Cells 2026; 18(9): 122395
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i9/122395.htm |
| DOI |
https://doi.org/10.4252/wjsc.122395 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
