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Articles Published Processes
10/29/2026 7:19:27 AM | Browse: 3 | Download: 0
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Received |
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2026-05-19 10:42 |
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Peer-Review Started |
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2026-05-19 10:42 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-22 06:43 |
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Revised |
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2026-07-06 03:38 |
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Publication Fee Transferred |
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2026-07-21 11:39 |
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Second Decision by Editor |
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2026-07-31 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-31 10:37 |
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Articles in Press |
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2026-07-31 10:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-20 04:02 |
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Publish the Manuscript Online |
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2026-10-29 07:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Prospective Study |
| Article Title |
Potential impact of generalized anxiety disorder on future hypertension risk: Investigating the role of psychophysiological stress pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Le-Rong Ouyang, Miao-Ling Zheng, Jin-Yi Hu, Qiu-Hong Li, Hu Xie, Xi Yang, Jian-Bin Xue and Xin-Yue Lin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xin-Yue Lin, MD, Cotton Ridge Community Health Service Center, Shenzhen Luohu Hospital Group, No. 2 Xinmian Road, Shenzhen 518019, Guangdong Province, China. 13410786720@163.com |
| Key Words |
Generalized anxiety disorder; Hypertension; Psychophysiological stress; Cortisol; Heart rate variability; Inflammation |
| Core Tip |
This prospective observational cohort study suggests that generalized anxiety disorder (GAD) is associated with future hypertension risk in a clinic-based population without baseline hypertension. Among the 300 participants, the 12-month incidence of sustained new-onset hypertension was higher in the GAD group (37.5% vs 6.9%). This association persisted after expanded adjustment for clinical variables, psychotropic/hypnotic medication use, physical activity, and dietary salt intake (adjusted odds ratio = 2.31). Patients with GAD also showed higher cortisol, C-reactive protein, and interleukin-6 levels and impaired heart rate variability. Exploratory mediation analysis supported cortisol and heart rate variability as possible statistical links; however, causal interpretation requires longer-term studies with repeated biomarker measurements. |
| Publish Date |
2026-10-29 07:19 |
| Citation |
Ouyang LR, Zheng ML, Hu JY, Li QH, Xie H, Yang X, Xue JB, Lin XY. Potential impact of generalized anxiety disorder on future hypertension risk: Investigating the role of psychophysiological stress pathways. World J Psychiatry 2026; 16(11): 122420
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i11/122420.htm |
| DOI |
https://doi.org/10.5498/wjp.122420 |
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