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11/9/2026 4:15:45 AM | Browse: 2 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 122422
Country China
Received
2026-04-20 08:00
Peer-Review Started
2026-04-20 08:00
First Decision by Editorial Office Director
2026-05-26 08:34
Return for Revision
2026-05-26 08:34
Revised
2026-06-15 05:10
Publication Fee Transferred
2026-06-24 08:12
Second Decision by Editor
2026-06-30 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-30 08:17
Articles in Press
2026-06-30 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-10-25 14:17
Publish the Manuscript Online
2026-11-09 04:15
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Retrieval-augmented generation models for predicting pathological upgrading in endoscopically resected gastric low-grade intraepithelial neoplasia: A dual-center evaluation
Manuscript Source Unsolicited Manuscript
All Author List Qian Zhuang, Jin-Nian Cheng, Yu-Lu Zheng, Shan Wu, Yi-Min Chu, Lu Zhou, Jie Xia, Min Ning, Hai-Xia Peng, Xin-Jian Wan and Zhi-Xia Dong
ORCID
Author(s) ORCID Number
Hai-Xia Peng http://orcid.org/0000-0002-2417-051X
Xin-Jian Wan http://orcid.org/0000-0002-4201-633X
Zhi-Xia Dong http://orcid.org/0000-0001-7474-5548
Funding Agency and Grant Number
Funding Agency Grant Number
the Shanghai Municipal Health Commission Health Industry Clinical Research Project of China 20234Y0016
the National Key Research and Development Program of China 2023YFC2413803
the National Key Research and Development Program of China 2023YFC2413806
the Shanghai Municipal Health Commission Smart Healthcare Special Research Project of China 2025ZHYL021
the Emerging Frontier Project of the Shenkang Development Center, China SHDC12024124
the Key Discipline Project of the Shanghai Municipal Health System, China 2024ZDXK0004
Corresponding Author Zhi-Xia Dong, Chief Physician, MD, Professor, Digestive Endoscopic Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600, Yi Shan Road, Shanghai 200233, Please enter the state or province, China. dzhixia2013@163.com
Key Words Large language model; Retrieval-augmented generation; Gastric low-grade intraepithelial neoplasia; Pathological upgrading; Predictive modeling; Endoscopic submucosal dissection; Artificial intelligence; Clinical decision support
Core Tip This study evaluated a novel retrieval-augmented generation (RAG) -enhanced large language model framework using dual-center data to predict pathological upgrading in gastric low-grade intraepithelial neoplasia. The RAG-enhanced DeepSeek-V3 and Qwen3-235b models achieved areas under the curve of 0.873 [95% confidence interval (95%CI): 0.828-0.901] and 0.862 (95%CI: 0.818-0.893), respectively, demonstrating performance comparable to experienced endoscopists and confirming their potential clinical utility.
Publish Date 2026-11-09 04:15
Citation

Zhuang Q, Cheng JN, Zheng YL, Wu S, Chu YM, Zhou L, Xia J, Ning M, Peng HX, Wan XJ, Dong ZX. Retrieval-augmented generation models for predicting pathological upgrading in endoscopically resected gastric low-grade intraepithelial neoplasia: A dual-center evaluation. World J Gastroenterol 2027; 33(1): 122422

URL https://www.wjgnet.com/1007-9327/full/v33/i1/122422.htm
DOI https://doi.org/10.3748/wjg.122422
Full Article (PDF) WJG-33-122422-with-cover.pdf