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Articles Published Processes
9/1/2026 4:34:33 AM | Browse: 0 | Download: 0
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Received |
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2026-04-23 06:22 |
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Peer-Review Started |
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2026-04-23 06:22 |
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First Decision by Editorial Office Director |
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2026-05-21 08:18 |
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Return for Revision |
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2026-05-21 08:18 |
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Revised |
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2026-06-25 04:58 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-07-27 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-28 13:07 |
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Articles in Press |
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2026-07-28 13:07 |
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Edit the Manuscript by Language Editor |
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2026-08-02 22:33 |
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Typeset the Manuscript |
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2026-08-24 07:55 |
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Publish the Manuscript Online |
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2026-09-01 04:34 |
| ISSN |
2150-5349 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keerthika Selvaraj and Chandrashekaran Girish |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chandrashekaran Girish, Professor, Department of Pharmacology, Jawaharlal Institute of Post Graduate Medical Education and Research, JIPMER Campus Road, Gorimedu, Puducherry 605006, Dhanvantari Nagar, India. gcnx2005@gmail.com |
| Key Words |
Antimicrobial peptide; Gut microbiota; Antimicrobial resistance; Immunomodulation; Intestinal barrier integrity; Inflammatory bowel disease; Nanotechnology-based delivery; Artificial intelligence in peptide design; Microbiome-targeted therapeutics |
| Core Tip |
Antimicrobial peptides (AMPs) represent promising next-generation therapeutics that counter antimicrobial resistance through membrane disruption, immune modulation, and microbiome regulation. Their dual role in host defense and tissue homeostasis- particularly within gastrointestinal environments-underscores their broader physiological significance. Advances in artificial intelligence-driven peptide design and nanotechnology-based delivery systems are progressively addressing pharmacokinetic limitations and enhancing clinical viability. However, challenges including cytotoxicity, proteolytic instability, and high production costs remain. Integrating bioengineering, precision medicine, and microbiome-guided strategies holds considerable potential for establishing AMPs as personalized, clinically translatable anti-infective and immunomodulatory therapeutics. |
| Publish Date |
2026-09-01 04:34 |
| Citation |
Selvaraj K, Girish C. Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy. World J Gastrointest Pharmacol Ther 2026; 17(3): 122448
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| URL |
https://www.wjgnet.com/2150-5349/full/v17/i3/122448.htm |
| DOI |
https://doi.org/10.4292/wjgpt.122448 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
