Publication Name	World Journal of Pharmacology
Manuscript ID	12246
Country	Australia

Received	2014-06-28 21:27
Peer-Review Started	2014-06-29 18:18
To Make the First Decision	2014-08-14 14:36
Return for Revision	2014-08-18 10:30
Revised	2014-09-03 14:08
Second Decision	2014-09-24 16:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-24 16:22
Articles in Press	2014-09-24 16:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-28 17:55
Publish the Manuscript Online	2014-12-12 11:14

ISSN	2220-3192 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Minireviews
Article Title	Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding
Manuscript Source	Invited Manuscript
All Author List	Hilai Ahmadzai, Lisa BG Tee and Andrew Crowe
Funding Agency and Grant Number
Corresponding Author	Dr. Andrew Crowe, School of Pharmacy and Curtin Health Innovation Research Institute, Curtin University, Kent Street, Bentley, WA 6102, Australia. a.p.crowe@curtin.edu.au
Key Words	Active efflux transporters; Lactation; Breastfeeding; Mammary gland; Breast cancer resistance protein; P-glycoprotein; Breast milk; ABC transporters
Core Tip	The aim of this review was to analyse the available literature on psychoactive drugs specifically selective serotonin reuptake inhibitors, antipsychotics and antiepileptic drugs that are commonly prescribed during lactation and pregnancy. This review investigated whether these drugs are substrates and/or inhibitors of efflux transporters especially of P-glycoprotein and breast cancer resistance protein and whether this has any effect on adverse outcomes in the breastfed infant of mothers who use these pharmacotherapeutic agents. Current evidence on acute adverse effects in breastfed infants due to the aforementioned drug groups either as sole treatment or their use in combination with other drugs was also explored.
Publish Date	2014-12-12 11:14
Citation	Ahmadzai H, Tee LBG, Crowe A. Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding. World J Pharmacol 2014; 3(4): 153-161
URL	http://www.wjgnet.com/2220-3192/full/v3/i4/153.htm
DOI	http://dx.doi.org/10.5497/wjp.v3.i4.153

Full Article (PDF)	WJP-3-153.pdf
Full Article (Word)	WJP-3-153.doc
Manuscript File	12246-Review.docx
Answering Reviewers	12246-Answering reviewers.pdf
Copyright License Agreement	12246-Copyright assignment.pdf
Peer-review Report	12246-Peer review(s).pdf
Scientific Misconduct Check	12246-CrossCheck.jpg
Scientific Editor Work List	12246-Scientific editor work list.pdf