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Articles Published Processes
9/2/2026 6:21:35 AM | Browse: 0 | Download: 0
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Received |
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2026-04-27 03:10 |
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Peer-Review Started |
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2026-04-27 03:13 |
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First Decision by Editorial Office Director |
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2026-06-08 07:32 |
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Return for Revision |
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2026-06-08 07:32 |
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Revised |
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2026-06-27 20:26 |
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Publication Fee Transferred |
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2026-07-06 13:57 |
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Second Decision by Editor |
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2026-07-13 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-13 03:29 |
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Articles in Press |
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2026-07-13 03:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-21 08:32 |
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Publish the Manuscript Online |
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2026-09-02 06:21 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Salem H Al-Qurashi, Muhammad Abdul Mabood Khalil, Hinda Hassan Khideer Mahmood, Alfatih Abdalla Altom, Yara Faisal Alqurashi, Zeyad Adel Alsaedi, Aileen Jean Dela Cruz, Maram Majid Alsharif, Rayan Mohammed Bawayan, Abdulrahman A Housawi and Nihal Mohammed Sadagah |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammad Abdul Mabood Khalil, FRCP, Renal Diseases and Transplantation Centre, King Fahad Armed Forces Hospital, Jeddah, Al Kurnaysh Br Rd, Al Andalus, Jeddah 23311, Makkah al Mukarramah, Saudi Arabia. doctorkhalil1975@hotmail.com |
| Key Words |
Kidney transplantation; Donor-specific antibodies; Human leukocyte antigen mismatch; Acute rejection; Graft function; Middle East |
| Core Tip |
In this large single-center study from the Middle East, pretransplant donor-specific antibodies (DSA) were frequently observed but were not independently associated with rejection or survival after accounting for other factors. Instead, a higher human leukocyte antigen mismatch burden (≥ 7) and poorer early graft function were more closely associated with adverse outcomes. These findings suggest that with current induction strategies, particularly the widespread use of antithymocyte globulin (ATG), the effect of preformed DSA may be less pronounced than traditionally expected. In everyday practice, this highlights the importance of looking beyond antibody status alone and paying closer attention to donor-recipient matching and early graft performance when assessing risk after transplantation. However, the high use of ATG and the relatively short follow-up may have attenuated or delayed the detectable impact of DSA on graft outcomes, particularly late rejection or chronic antibody-mediated injury. |
| Publish Date |
2026-09-02 06:21 |
| Citation |
Al-Qurashi SH, Khalil MAM, Mahmood HHK, Altom AA, Alqurashi YF, Alsaedi ZA, Cruz AJD, Alsharif MM, Bawayan RM, Housawi AA, Sadagah NM. Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia. World J Transplant 2026; 16(3): 122485
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| URL |
https://www.wjgnet.com/2220-3230/full/v16/i3/122485.htm |
| DOI |
https://doi.org/10.5500/wjt.122485 |
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