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Articles Published Processes
10/15/2026 5:45:57 AM | Browse: 1 | Download: 2
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Received |
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2026-04-22 06:49 |
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Peer-Review Started |
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2026-04-22 06:51 |
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First Decision by Editorial Office Director |
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2026-05-27 06:23 |
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Return for Revision |
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2026-05-27 06:23 |
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Revised |
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2026-06-25 03:33 |
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Publication Fee Transferred |
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2026-07-01 15:41 |
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Second Decision by Editor |
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2026-07-13 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-13 09:24 |
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Articles in Press |
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2026-07-13 09:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-29 14:38 |
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Publish the Manuscript Online |
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2026-10-15 05:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Xin Zhang, Xin-Yi Fang, Yan-Jiao Zhang, Rui-Yang Yin, Bin Li and Jia-Xing Tian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| GAMIMD Special Fund |
2022LYJSZX12 |
| CACMS Outstanding Young Scientific and Technological Talents Program |
ZZ13-YQ-026 |
| CACM-PDP Dose-Effect Relationship Research Project |
202428-002 |
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| Corresponding Author |
Jia-Xing Tian, Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China. tina-yai@126.com |
| Key Words |
Tangwei’an decoction; Diabetic gastroparesis; Multi-omics; COX6A2/SCF/c-Kit; Mitochondrial dynamics |
| Core Tip |
Tangwei’an decoction (TWAD) is clinically used for diabetic gastroparesis (DGP), but its mechanism remains unclear. This study combined serum pharmacochemistry, integrated proteomics and metabolomics, and experimental validation to show that TWAD alleviates DGP by restoring mitochondrial dynamics. Oxidative phosphorylation was identified as the major pathway regulated by TWAD, with COX6A2 as a key target. TWAD also modulated the SCF/c-Kit axis, providing mechanistic support for its therapeutic potential in DGP. |
| Publish Date |
2026-10-15 05:45 |
| Citation |
Zhang YX, Fang XY, Zhang YJ, Yin RY, Li B, Tian JX. Multi-omics analysis identifies COX6A2/SCF/c-Kit-mediated mitochondrial remodeling as a key mechanism of Tangwei’an decoction in diabetic gastroparesis. World J Gastroenterol 2026; 32(45): 122523
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i45/122523.htm |
| DOI |
https://doi.org/10.3748/wjg.122523 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
