| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Jing Ye, Esraa Ali, Sergii Pavlov, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Petr Hošek, Ondřej Daum, Václav Liška, Kari Hemminki and Andriy Trailin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Health of Czech Republic |
NU21-03-00506 |
| Ministry of Health of Czech Republic |
NW24-03-00521 |
| Cooperatio Program, Research Area SURG |
|
| SALVAGE Project (OP JAK; co-financed by the European Union and the State Budget of the Czech Republic) |
CZ.02.01.01/00/22_008/0004644 |
| Integration of Biomedical Research and Health Care in the Pilsen Metropolitan Area (co-funded by the European Union and by the State Budget of the Czech Republic) |
CZ.02.01.01/00/23_021/0008828 |
|
| Corresponding Author |
Andriy Trailin, Laboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, Pilsen 32300, Czech Republic. andriy.trailin@lfp.cuni.cz |
| Key Words |
Neutrophils; Mast cells; Primary colorectal cancer; Liver metastases; Adjacent non-tumor mucosa; Tumor microenvironment; Survival |
| Core Tip |
Densities of polymorphonuclear neutrophils (PMNs) and mast cells (MCs) showed distinct spatial patterns across colorectal cancer (CRC) progression, with PMNs increasing and MCs decreasing from nontumor mucosa through primary CRC (pCRC) to liver metastases (LM). MCs in pCRC exhibited protumor associations with survival, whereas PMNs showed context-dependent survival associations, being unfavorable in stage I-III pCRC and synchronous LM but favorable in metachronous LM. These findings highlight dynamic, stage- and site-specific roles of PMNs and MCs and after validation may serve as prognostic biomarkers for CRC patients. |
| Publish Date |
2026-10-09 08:15 |
| Citation |
Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Daum O, Liška V, Hemminki K, Trailin A. Context-dependent prognostic role of neutrophils and mast cells in primary colorectal cancer and liver metastases. World J Gastrointest Oncol 2026; 18(10): 122608
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i10/122608.htm |
| DOI |
https://doi.org/10.4251/wjgo.122608 |
