| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Endogenous metabolites as active drivers of acute pancreatitis: Mechanisms and advances in targeted therapy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang Lu, Yu Zeng, Li Li, Jian-Qin Liu, Xin Zhou, Xiao-Ning Jin, Chao-Li Jiang and Zhi Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project of Sichuan Administration of Traditional Chinese Medicine |
No. 2024zd035 |
| Sichuan University and Luzhou Municipal People’s Government Strategic cooperation projects |
No. 2020CDLZ-18 |
| Southwest Medical University Technology Program |
No. 2023ZYQJ03 |
|
| Corresponding Author |
Zhi Li, Academic Fellow, Chief Physician, MD, PhD, Professor, Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182 Chunhui Road, Longmatan District, Luzhou 646000, Sichuan Province, China. lizhi-scholar@swmu.edu.cn |
| Key Words |
Acute pancreatitis; Metabolic network; Metabolomics; Targeted therapy; Drug repurposing; Mitochondrial dysfunction; Gut microbiota |
| Core Tip |
Acute pancreatitis still has no therapy directed at its core mechanisms, and treatment remains supportive. Metabolomic studies have revealed widespread disturbance of metabolic pathways during the disease, and accumulating evidence indicates that these changes are not merely markers but active contributors to acinar injury, inflammatory amplification, and immune dysregulation. This review classifies the relevant metabolites by origin host enzymes, gut microbes, or the cooperation of both and examines eight pathways together with the interventions being tested for each. It treats the mitochondrion as a point where several injurious pathways converge and the gut as a source of metabolites that act on the pancreas from a distance. Because the contribution of each pathway shifts as the disease evolves, it also considers how interventions might be matched to the disease phase. As the evidence is still largely preclinical, the framework is meant to guide further study rather than current treatment. |
| Publish Date |
2026-10-27 06:30 |
| Citation |
Lu X, Zeng Y, Li L, Liu JQ, Zhou X, Jin XN, Jiang CL, Li Z. Endogenous metabolites as active drivers of acute pancreatitis: Mechanisms and advances in targeted therapy. World J Gastroenterol 2026; 32(47): 122664
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i47/122664.htm |
| DOI |
https://doi.org/10.3748/wjg.122664 |
