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Articles Published Processes
10/27/2026 6:30:54 AM | Browse: 1 | Download: 0
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Received |
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2026-04-27 08:22 |
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Peer-Review Started |
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2026-04-27 08:23 |
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First Decision by Editorial Office Director |
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2026-05-28 10:37 |
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Return for Revision |
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2026-05-28 10:37 |
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Revised |
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2026-06-26 09:36 |
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Publication Fee Transferred |
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2026-07-13 02:26 |
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Second Decision by Editor |
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2026-07-28 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-28 13:06 |
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Articles in Press |
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2026-07-28 13:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-07 03:54 |
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Publish the Manuscript Online |
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2026-10-27 06:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Zfp36 zinc finger CCCH-type inhibits gastric cancer progression by upregulating lipase G and binding its 3’ untranslated region
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Jie Yu, Sheng-Mao Zhu, Bao-Jia Cai, Xiao-Ming Ma, Wen-Jie Qiao, Jing-Jun Han and Cheng-Wu Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Qinghai Provincial Department of Science and Technology |
2023-ZJ-787 |
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| Corresponding Author |
Cheng-Wu Zhang, Professor, Department of Gastrointestinal Oncology Surgery, Qinghai University Affiliated Hospital (School of Clinical Medicine), No. 29 Tongren Road, Chengdong District, Xining 810001, Qinghai Province, China. 952068360@qq.com |
| Key Words |
Zfp36 zinc finger CCCH-type; Gastric cancer; Lipase G; RNA-binding protein; 3’ untranslated region |
| Core Tip |
Zfp36 zinc finger CCCH-type (ZFP36), an RNA-binding protein, has an unclear role in gastric cancer. Here, ZFP36 overexpression in AGS cells suppressed proliferation, migration, and invasion, as well as G0/G1-phase arrest and apoptosis induction, while also inhibiting xenograft tumor growth. Integrated RNA sequencing and improved RNA immunoprecipitation sequencing identified lipase G (LIPG) as a direct target, with ZFP36 binding to its 3’ untranslated region to enhance LIPG expression. In vivo, LIPG was upregulated in ZFP36-overexpressing tumors. These findings demonstrate that ZFP36 inhibits gastric cancer progression by upregulating LIPG, revealing a potential therapeutic axis. |
| Publish Date |
2026-10-27 06:30 |
| Citation |
Yu PJ, Zhu SM, Cai BJ, Ma XM, Qiao WJ, Han JJ, Zhang CW. Zfp36 zinc finger CCCH-type inhibits gastric cancer progression by upregulating lipase G and binding its 3’ untranslated region. World J Gastroenterol 2026; 32(47): 122668
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i47/122668.htm |
| DOI |
https://doi.org/10.3748/wjg.122668 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
