| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Fang Chen, Yuan-Yuan Chen, Fei-Tian Min, Wei-Bo Wen, Su-Feng Luo, Ya Luo, Qin-Rong Li, Zi-Qing Xu, Sha-Sha Liu, Xia Chen, Ning Wang, Huan-Tian Cui and Xiao-Rong Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2025 Yunnan Provincial International Science and Technology Commissioner (Individual) Certification Program |
No. 202503AK140045 |
| Open Research Fund Program of Yunnan Key Laboratory for Dai and Yi Medicines (Yunnan University of Chinese Medicine) |
No. 2025ZD2502 |
|
| Corresponding Author |
Huan-Tian Cui, PhD, Post Doctoral Researcher, Principal Investigator, Senior Researcher, The First School of Clinical Medicine, Yunnan University of Chinese Medicine, No. 1076 Yuhua Road, Chenggong District, Kunming 650500, Yunnan Province, China. 1762316411@qq.com |
| Key Words |
Colitis-associated colorectal cancer; Ya-Han-Lu-Duan decoction; Arachidonic acid metabolism; Cancer-associated fibroblasts; Myeloid-derived suppressor cells |
| Core Tip |
Ya-Han-Lu-Duan (YHLD) decoction exerts a significant protective effect against colitis-associated colorectal cancer. YHLD remodels the immunosuppressive tumor microenvironment by suppressing cancer-associated fibroblast activation and myeloid-derived suppressor cells infiltration. YHLD is likely to inhibit ALOX12-mediated and PTGS2-mediated arachidonic acid metabolism in cancer-associated fibroblasts and myeloid-derived suppressor cells through multiple active components. |
| Publish Date |
2026-10-27 06:30 |
| Citation |
Chen LF, Chen YY, Min FT, Wen WB, Luo SF, Luo Y, Li QR, Xu ZQ, Liu SS, Chen X, Wang N, Cui HT, Wang XR. Ya-Han-Lu-Duan decoction reshapes tumor microenvironment to treat colitis-associated colorectal cancer by regulating arachidonic acid metabolism. World J Gastroenterol 2026; 32(47): 122777
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i47/122777.htm |
| DOI |
https://doi.org/10.3748/wjg.122777 |
