9/23/2026 8:57:27 AM | Browse: 3 | Download: 5
| Publication Name | World Journal of Clinical Oncology |
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| Manuscript ID | 122832 |
| Country | China |
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| ISSN | 2218-4333 (online) |
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| Open Access | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Oncology | ||||||
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| Manuscript Type | Basic Study | ||||||
| Article Title | Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Zi-Feng Deng, Lei Zhao, Ye Yuan, Li-Kun Li, Mu-Ya Ge, Liang-Ding Dou, Jin-Wen Zhang, Dai Wang, Dong-Bei Guo, Ran An, Yong-Xing Zhang and Bo Song | ||||||
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| Corresponding Author | Bo Song, Chief Physician, PhD, Professor, Air Force Hospital of Eastern Theater, Nanjing University of Chinese Medicine, No.1 Changfu Road, MaLu Road, Nanjing 230032, Jiangsu Province, China. 23822520@qq.com | ||||||
| Key Words | Lung cancer; A-kinase anchoring protein 95; Degradation of cyclins; SCFFBXL2 and SCFFBXO31; CPSF5/6 | ||||||
| Core Tip | This study links mechanistic findings to clinical evidence in lung cancer. Immunohistochemical analysis of 40 tumor specimens showed that AKAP95 was negatively correlated with the SCFFBXO31, whereas Cx43 was positively correlated with SCFFBXO31. Complementary cell experiments supported opposing effects of AKAP95 and Cx43 on SCFFBXO31 expression. Together, these findings provide clinical support for a proposed pathway through which the AKAP95-Cx43 axis regulates cyclin D1 degradation and cell-cycle progression. | ||||||
| Publish Date | 2026-09-23 08:57 | ||||||
| Citation |
Deng ZF, Zhao L, Yuan Y, Li LK, Ge MY, Dou LD, Zhang JW, Wang D, Guo DB, An R, Zhang YX, Song B. Correlations of the expression of AKAP95, Cx43, CPSF5/6, SCFFBXL2 and SCFFBXO31 in lung cancer tissues. World J Clin Oncol 2026; 17(9): 122832 |
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| URL | https://www.wjgnet.com/2218-4333/full/v17/i9/122832.htm | ||||||
| DOI | https://doi.org/10.5306/wjco.122832 |
| Full Article (PDF) | WJCO-17-122832-with-cover.pdf |
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| Manuscript File | 122832_Auto_Edited_014351.docx |
| Answering Reviewers | 122832-answering-reviewers.pdf |
| Audio Core Tip | 122832-audio.mp3 |
| Biostatistics Review Certificate | 122832-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 122832-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 122832-copyright-assignment.pdf |
| Institutional Review Board Approval Form or Document | 122832-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 122832-non-native-speakers.pdf |
| Peer-review Report | 122832-peer-reviews.pdf |
| Scientific Misconduct Check | 122832-scientific-misconduct-check.png |
| CrossCheck Report | 122832-crosscheck-report.pdf |